Scott D. Zawieja

The paper identifies a GATA2-PROX1-FOXC2 regulatory axis that integrates shear stress signaling with lymphatic vascular development, showing dosage-dependent cooperation between GATA2 and FOXC2.

This study identifies a Gαq/11-IP3R1-ANO1 signaling axis responsible for pressure-induced lymphatic contractions in mouse popliteal vessels.

This study identifies TRPV4-expressing macrophages as regulators of lymphatic vessel function through TXA2 receptors, suggesting therapeutic targets for lymphedema.

This study shows that S1PR1 regulates lymphatic valve development and prevents tertiary lymphoid organ formation in the terminal ileum, suggesting TLOs as a sign of subclinical inflammation.

This study identifies lymphatic muscle cells as the pacemaker cells in mouse collecting lymphatic vessels through combined immunofluorescence, scRNA-seq, and electrophysiological analyses.

This paper compares two CreERT2 mice, showing Itga8-CreERT2 avoids a lethal intestinal phenotype seen with Myh11-CreERT2 when knocking out Srf.