Jianzhu Chen

This paper develops LIME, a bacterial platform that engagers T and NK cells to target tumors, showing enhanced cytotoxicity and immune response in preclinical models.

This paper shows that E. faecalis uses lactic acid to suppress macrophage activation, enabling persistent and polymicrobial wound infections.

This study enhances the immunogenicity of viral capsid proteins by engineering them into membrane-bound or secreted forms, showing improved folding and T cell responses in animal models.

The paper selects and evaluates ASFV antigens for subunit mRNA vaccines, showing divergent immune responses and developing a computational method to design antigen cocktails.

This paper shows bosutinib enhances macrophage phagocytosis and bacterial killing, reducing infection in mice.