NF-κB Signaling Pathways

The paper compares different A20 feedback implementations in NF-κB signaling models to determine their impact on dynamics, finding that one model aligns with experimental data.

The paper presents a detailed pathway network model of the NF-κB pathway, including post-translational modifications and interactions, showing qualitative agreement with experimental data.

This study identifies SPSB1 as a negative regulator of NF-κB activation, showing its specificity for NF-κB and its role in inflammation and innate immunity.

The paper shows NF-κB differentiates cytokine input doses by using negative feedback loops to track changes in concentration rather than absolute levels.

This study uses deep learning and live-cell analysis to show that NF-κB activation in single cells is pre-determined by pre-stimulation nuclear localization ratios of NF-κB to IκB.

The paper reveals that p100 modulates NF-κB responses to TNF by enabling a late RelB:p50 activity that alters gene expression programs.

The paper identifies stimulus-specific RELA binding sites in human cells and shows their association with antiviral gene regulation and IRF motifs.

The paper shows that Cactus promotes Toll signals in Drosophila embryos by modulating Dorsal nuclear localization, revealing differential behavior of the Dorsal gradient in response to Cactus concentrations.