Soumen Basak

The paper shows that cell death, not type-1 interferons, limits Chandipura virus propagation at high multiplicity of infection.

The paper develops a mathematical model to show how NFκB and IRF-3 co-regulate IFNβ expression during viral infections, with NFκB driving immediate response and IRF-3 causing delayed but persistent expression.

The paper reveals that p100 modulates NF-κB responses to TNF by enabling a late RelB:p50 activity that alters gene expression programs.