Assisted Reproductive Technology and Twin Pregnancy

The paper uses post-zygotic mutations to analyze clonal dynamics in monozygotic twins and finds three clonal categories correlated with amnionicity, not chorionicity.

The paper develops a polygenic score for dizygotic twinning, showing it explains 1.6% of liability variance and is linked to fertility outcomes and genetic correlations with related conditions.

This study examines sex-specific DNA methylation and variability differences in placental tissue between IVF and spontaneous pregnancies, identifying significant shifts in variability and cell composition.

This study examines DNA methylation, imprinting, and gene expression in placentas from ART and control groups, identifying molecular changes linked to ART and subfertility.

The paper compares transcriptomic and metabolomic data from monozygotic and dizygotic twins to identify molecular biomarkers of twinning, finding no replicable transcript-level differences but highlighting potential pathways.

The paper uses whole-genome sequencing to determine zygotic composition in chimeric twins, finding asymmetrical contributions from two zygotes in blood but not in buccal tissues.

The paper identifies mtDNA variants in ART and spontaneously conceived individuals linked to lower birth weight, showing sex-dependent effects and maternal aging influences.

The paper describes the Babytwins Study Sweden (BATSS), a longitudinal twin study combining EEG, eye tracking, genetics, and behavioral assessments to investigate genetic and environmental influences on infant brain and behavioral development.

This study examines the epigenetic effects of assisted reproductive technologies on human offspring, finding that certain procedures introduce DNA methylation changes linked to long-term health risks.