Ocular Infections and Treatments

This study shows that Pseudomonas aeruginosa infection causes mitochondrial fission and metabolic changes in corneal epithelial cells, which are reversed after antibiotic treatment.

This study identifies FDA-approved compounds that inhibit ExoU, a virulence factor in Pseudomonas aeruginosa, and shows their efficacy in reducing corneal infection severity in multiple models.

The paper shows that Exotoxin A is not essential for bacterial survival or corneal disease severity in P. aeruginosa keratitis in mice.

The paper shows that prior contact lens wear reduces bacterial adhesion to superficially-injured corneas in mice, correlating with increased Lyz2+ immune cells, but with differing effects on commensal and pathogen behavior.

The paper evaluates rotational fluoroquinolone therapy for ophthalmic MRSA infections, showing it improves bacterial clearance compared to monotherapy by leveraging resistance profiles and pharmacokinetics.

This study investigates the role of miR-183C in corneal sensory nerves during Pseudomonas aeruginosa keratitis, showing its impact on nerve degeneration and immune cell dynamics.

This study identifies HAdV-D-specific mechanisms of HMGB1 secretion and subepithelial infiltrate formation in EKC by infected corneal epithelial cells.

This paper introduces an ex vivo porcine corneal infection model using plumbing rings to improve antimicrobial application and assess its efficacy against Pseudomonas aeruginosa.

This study shows that contact lens wear changes corneal epithelium and bacterial gene expression responses to Pseudomonas aeruginosa, promoting bacterial virulence and adaptation.

This paper investigates the antifungal properties of 4μ8C, an Ire1 inhibitor, showing strong activity against Aspergillus fumigatus in vitro and in a fungal keratitis treatment model.

This study develops a non-human primate model of acute trachoma and characterizes the local immune response kinetics following Chlamydia trachomatis infection.

This study compares metagenomic DNA sequencing with pathogen-directed PCR for diagnosing intraocular infections, finding DNA-seq detects more pathogens and identifies drug resistance mutations.