Spaceflight effects on biology

The paper shows that gravity and mechanical forces influence mitochondrial translation by affecting signaling pathways and malonylation of the translational machinery.

This study uses RNA-Seq data from GeneLab to assess DNA sequence variants linked to spaceflight stress, finding more mutations in spaceflight samples than controls.

The paper evaluates how simulated Martian gravity and visual-vestibular conflicts affect tandem walking performance in a virtual reality environment.

This study examines how weightlessness affects astronauts' gaze behavior during space shuttle flights, finding changes related to flight day and target eccentricity.

The paper uses RNA sequencing on muscle biopsies from a bed-rest study to show exercise reduces deconditioning-related gene expression changes and ligand-receptor interactions with DRG neurons.

The paper assesses bone stimulation through head and trunk acceleration measurements in healthy subjects to evaluate their sufficiency in maintaining bone mineral density.

This study examines how long-duration spaceflight affects sensorimotor control and cognition, finding transient declines in mobility, balance, and bimanual coordination that recover within 30 days, while cognitive performance remains stable.

The paper distinguishes T cell responses to simulated microgravity and hydrodynamic stress using transcriptomic analysis and identifies differentially expressed genes associated with each condition.

The paper shows genetic differences affect bone loss in mice under unloading, with specific strains showing greater bone volume and strength loss.

The paper examines the impact of simulated microgravity on DNA damage response in zebrafish embryos and compares it to human spaceflight effects observed in the NASA twin study.

GraviKit enables gravity-dependent imaging with a horizontal beampath by converting standard microscopes into devices with a rotatable stage.

This study examines how spaceflight affects MRI-visible perivascular spaces (PVSs) in astronauts, finding that novice astronauts show increased PVS volume post-flight, while experienced astronauts show baseline correlations between flight days and PVS length.

This study examines resting-state functional connectivity changes in a spaceflight analog, finding distinct patterns in those who develop optic disc edema compared to those who do not.

This study investigates how alternative splicing and differential gene expression contribute to muscle adaptation to microgravity in mice, finding that AS plays a major role in transcriptomic changes.

This study shows spaceflight alters the DNA methylome and transcriptome in mouse retinas, slowing the epigenetic clock and affecting disease-related pathways.

This study shows that spaceflight causes dendritic remodeling and impaired clearance of neuronal debris in adult C. elegans neurons.

This study examines how a spaceflight analog environment with elevated CO2 affects brain connectivity and sensorimotor performance over time.

The paper exposes male mice to space radiation and finds no detrimental effect on high-level cognition, with improved pattern separation performance.

The paper introduces a synthetic RNA-based microgravity sensor in E. coli that alters target protein expression in response to microgravity, demonstrating its potential for space biotechnology applications.

The paper shows that RNAseq analysis of rodent spaceflight experiments is confounded by sample collection and preservation techniques, with preservation effects overshadowing spaceflight effects.

This study investigates how microgravity affects perspective-taking abilities, finding it selectively enhances mental rotations in the frontal plane and varies by visual field dependence.

This study shows that Caenorhabditis elegans senses and responds to gravity through an active behavior requiring gravisensation, with gravity response declining with age.

This study identifies the transcriptomic response of C. elegans to simulated microgravity and shows that 75% of gene expression changes persist for four days post-exposure.