Spaceflight effects on biology

This study examines transgenerational effects of Martian analog gravity and hypomagnetic fields on C. elegans, finding progressive impairments and increased phenotypic variability across generations.

This study modifies a computational model to simulate microbial growth in microgravity, finding that reduced gravity-driven flow decreases growth while lack of sedimentation increases it.

ibSLS provides a platform for accessing multi-omics data and biospecimens from spaceflight research to support biomedical and disease studies.

The paper develops computational models to simulate how altered gravity affects neuronal activity, showing that microgravity increases firing rates and hypergravity decreases them through modified channel dynamics and mechano-gated channels.

This study examines long-term cognitive and bone health effects of low-dose helium ion exposure in rats, finding persistent neurobehavioral deficits and specific bone parameter changes.

The paper uses machine learning to identify molecular pathways associated with retinal damage in spaceflown mice, revealing distinct signatures for oxidative stress and apoptosis.

The paper develops an acoustic bioreactor to study 3D neuronal spheroids in microgravity and finds increased calcium activity under microgravity conditions.

This study examines how 3-week disuse affects calf and thigh muscle phenotype and gene expression, finding greater declines in calf muscles with specific proteomic and transcriptomic changes.

This paper reviews airborne infectious diseases in space and their potential effects on COVID-19 in microgravity, providing preparedness guidelines for space missions.

This study uses meter-scale 2D clinostats to simulate microgravity for tomato plants, revealing environmental factors like temperature influence growth responses.

This study examines how reduced gravity and muon flux affect viral infection and life history traits in Caenorhabditis elegans, revealing impacts on reproduction, morphology, and viral dynamics.

The paper investigates how altered gravity affects adrenergic-mediated cAMP signaling in intact cells, finding shifts in cAMP production EC50 and kinetics under hypergravity and microgravity.

This study examines how simulated space conditions affect viral infection in C. elegans, finding that abiotic stressors reduce viral replication and alter host gene expression.

The paper describes the design and operational considerations of a tissue-engineered skeletal muscle system for microgravity experiments to study muscle atrophy and aging mechanisms.

This study reviews and analyzes the effects of simulated microgravity on hematological and anemia-related biomarkers in humans, finding hemoconcentration, erythropoietin suppression, and altered iron metabolism.

The paper identifies conserved molecular pathways in spaceflight-induced sarcopenia using cross-species analysis and develops a model linking transcriptional changes to locomotion deficits.

This study validates the stability of gentamicin and streptomycin in agar plates over 6.5 months at 4°C, finding slight degradation but overall stability suitable for the GEARS project.

GLARE applies representation learning to spaceflight transcriptomics, confirming existing findings and uncovering new gene expression patterns in Arabidopsis under spaceflight conditions.

This study examines how simulated lunar gravity and heavy ion radiation affect mitochondrial quality control in mouse skeletal muscle, finding radiation suppresses key transcriptional regulators while simulated gravity has no effect.

This study uses a muscle lab-on-chip model on the ISS to show microgravity accelerates muscle degeneration, with younger muscles showing increased aging gene expression under microgravity when stimulated.

This study examines the effects of 10 g hypergravity on Arabidopsis thaliana biomass and element content, finding increased biomass but no changes in mineral element levels.

This study constructs dose-response curves for lower body negative pressure (LBNP) to quantify cardiovascular effects across different postures and identifies its potential to reduce jugular venous flow stagnation during spaceflight.

This study examines the effects of 28 days of spaceflight on the murine lumbar spine and proximal tibia, finding no significant changes in vertebral bone microarchitecture or intervertebral disc properties, but significant bone loss in the tibia.

Flight-Scope enables live-cell imaging of dynamic processes in microgravity using microfluidics during parabolic flights, demonstrated with yeast glucose uptake.

This study examines how low-intensity neuromuscular electrical stimulation affects gene expression and muscle phenotype during one week of disuse, showing mixed benefits depending on muscle type.

This study fermented miso on the International Space Station and found it is possible, with unique microbial and sensory characteristics compared to Earth-based controls.

This study simulates microbial proliferation in the space station under disinfection measures and finds that factors like low-dose ionizing radiation, dilution, and quaternary ammonium compound can synergistically promote microbial growth.

This study compares the effects of microgravity and hypergravity on sensorimotor control during reaching tasks, finding that hypergravity impairs accuracy while microgravity allows accurate performance.

This study examines sex-specific cardiovascular adaptations to simulated microgravity in rats, finding increased arterial stiffness in females but not males.

This study examines metabolic changes in chondrocytes under simulated microgravity, finding metabolic shifts linked to early osteoarthritis.