Axon Guidance and Neuronal Signaling

The paper quantifies developmental dynamics of retinocollicular projection ordering in mice and shows a combined activity-molecular model can capture segregation and convergence changes.

This paper identifies Fish-lips (Fili) as a transmembrane protein that mediates repulsion between non-synaptic partner neurons to ensure precise wiring in the Drosophila olfactory circuit.

This study identifies RHO-1 and RHGF-1 as negative regulators of growth cone protrusion and microtubule accumulation, acting downstream of UNC-6/Netrin signaling in C. elegans.

The paper investigates the functional roles of different structural motifs in Drosophila Plexin B during olfactory circuit assembly, revealing their distinct contributions to neurodevelopmental processes.

The paper identifies actin assembly and non-muscle myosin activity as drivers of dendrite retraction in a UNC-6/Netrin-dependent self-avoidance response in C. elegans.

This study shows that zebrafish dscaml1 is crucial for retinal patterning and oculomotor circuit function, with mutations causing deficits in gaze stabilization and saccade fatigue similar to human ocular motor apraxia.

The paper investigates how axon guidance cues determine subcellular synapse specificity in Drosophila neurons, showing that these cues, not distinct dendritic domains, dictate synaptic connections.

The paper shows how in vivo topology transforms competition for cell-matrix adhesion into directional migration through Sdf1 and Sema3A interactions.

This study shows that intrinsic temporal identity, determined by the Hunchback transcription factor, dictates axon and dendrite targeting in Drosophila motor neurons, overriding birth order.

The paper investigates how retinal EphA5 expression changes after injury and how these changes relate to retinocollicular map plasticity.

The paper shows that C. elegans amphid neurons form a multicellular rosette to collectively extend dendrites, using adhesion molecules and mechanical cues from surrounding tissues.

This study identifies Dystroglycan as an extracellular scaffold that coordinates axon guidance by interacting with environmental cues and the receptor Celsr3/Adgrc3.

The paper shows Nell2 is an ipsilateral layer-specific axon guidance cue in the visual thalamus that inhibits contralateral retinal axons, establishing eye-specific retinogeniculate projections.

The paper investigates how commissural axons develop sensitivity to midline repellents through receptor dynamics during navigation, revealing spatial and temporal receptor profiles that enable discrimination of repulsive signals.

The paper shows that DIP-α and Dpr10 IgSF proteins mediate stereotyped terminal axon branching of leg motor neurons in Drosophila through interactions between axon filopodia and muscles.

This study shows TIAM-1/GEF shapes dendrites in C. elegans by regulating F-actin localization without requiring its GEF activity.

This review discusses how Teneurin proteins use conserved mechanisms to regulate diverse developmental processes in the Drosophila nervous system, including axon guidance, partner matching, and synapse formation.

This study identifies Reelin's role in promoting fast, laterally-directed migration of midbrain dopaminergic neurons through stabilization of leading processes and induction of bipolar morphology.

This study investigates the roles of Robo1 and Robo2 in facial neuron migration and axon projection in mouse embryos, finding that their loss leads to migration and projection defects.

The paper shows that muscle precursors guide oculomotor nerve growth and branching in mouse embryos by acting as intermediate targets.

The paper identifies a specific glycine residue in CED-10/Rac1 that is critical for axon outgrowth but not guidance, revealing domain-specific functions in neuronal development.

This study identifies Ret51 as a marker for pioneer neurons and shows its role in axon growth and growth cone dynamics through retrograde transport.

This study shows that dystroglycan is essential for proper sorting of retinal ganglion cell axons at the optic chiasm, with missorted axons persisting into adulthood.

The paper quantifies dendrite arrangement in C. elegans and shows that cell adhesion molecules regulate their stereotyped order, which can be disrupted by genetic perturbations.

The paper shows that DIPs and Dprs control the organization of olfactory receptor neuron terminals in Drosophila by mediating class-specific self-adhesion and axon sorting.

The paper identifies protocadherin-mediated repulsion as critical for organizing the abducens nucleus's topography and neuromuscular connections in zebrafish.

This study identifies Rap2 and TNIK as regulators of Plexin-dependent synaptic tiling in C. elegans, showing their role in restricting presynaptic assembly and forming tiled innervation.

This paper investigates how UNC-6/Netrin and its receptors UNC-5 and UNC-40/DCC regulate growth cone polarity, microtubule organization, and protrusion during axon guidance in C. elegans.

The paper investigates how selective filopodia adhesion mediated by adhesion molecules ensures robust cell matching in Drosophila heart development.