Axon Guidance and Neuronal Signaling

The paper identifies genes that constrain dendrite growth in C. elegans throughout life, revealing a mechanism distinct from developmental growth pathways.

This study shows that TRIM67 is critical for brain development and behavior, with deletion causing anatomical and functional impairments in mice.

The paper identifies key proteins involved in axon guidance disorders using systems biology tools and analyzes their molecular mechanisms.

This study identifies CHW-1 as an atypical Rho GTPase involved in axon guidance in C. elegans, showing its genetic interaction with SAX-3 and requirement for proper axon pathfinding.

This study identifies Cas adaptor proteins as essential for DRG axon fasciculation and substrate adhesion during peripheral nervous system development.

The paper shows that starburst amacrine cells use homotypic contacts to initiate formation of a dendritic scaffold in the retina, which is critical for direction-selective circuitry.

The paper shows that dFezf coordinates laminar-specific connectivity in Drosophila by both cell-intrinsic and cell-extrinsic mechanisms.

The paper shows that Neurexin and Neuroligin adhesion complexes drive axonal arborisation growth without requiring synaptic activity.

The paper identifies that trigeminal ganglia axons are the earliest afferent projections to the mouse cerebellum, preceding Purkinje cell development.

The paper shows UNC-5 regulates UNC-40 asymmetric localization and outgrowth patterning in C. elegans neurons in response to extracellular cues.

This study identifies FMO-1, FMO-4, FMO-5, and EHBP-1 as new factors downstream of UNC-6/Netrin and Rac GTPases that inhibit growth cone protrusion during repulsive axon guidance in C. elegans.

This paper revisits chemoaffinity theory by developing a mathematical model of growth cone chemotaxis to explain how axons navigate to their correct targets in topographic maps.

The paper identifies 82 candidate connectivity labels in the developing thalamus using bioinformatics and clustering analyses of gene expression patterns.

This study investigates the role of Semaphorin-6A-Plexin-A2/Plexin-A4 signaling in thalamocortical axon guidance and subpallial development in mice.