Axon Guidance and Neuronal Signaling

This study identifies protein disulphide isomerase as a key mediator of axon repulsion barriers in somites, showing its role in nitric oxide signaling and growth cone regulation.

This study shows NUAK1 regulates cortical axon branching by modulating mitochondrial metabolism and positioning, with functional rescue observed through mitochondrial function upregulation.

This paper investigates the role of Rap/Fzr in Drosophila retinal axon targeting and its interactions with Loco and Liprin-alpha, showing defects in axon projection in mutants and enhanced phenotypes in double mutants.

The paper shows that reduced Tuba1a impairs axon guidance but supports neuronal migration, revealing TUBA1A's role in microtubule dynamics during neurodevelopment.

The paper shows that Wnt5 signaling through Vang and Drl/Ryk in Drosophila ORNs and PNs controls the rotation of DA1/VA1d glomeruli during antennal lobe development.

The paper shows that SlitC-PlxnA1 signaling limits growth cone exploration to ensure forward midline navigation, not post-crossing barrier mechanisms.

The paper shows that autophagy regulates axonal filopodia kinetics, which restricts incorrect synaptic partner choice during Drosophila brain development.

This study shows that inhibiting Reelin cleavage enhances its signaling, leading to hippocampal layer disturbances and increased dendritic branching, suggesting Reelin cleavage is critical for normal brain development.

This study shows that βIII spectrin regulates dendrite planarity by controlling microtubule dynamics and preventing abnormal lateral branching in Purkinje cells.

The paper introduces a generative model for axonal branching in the primary visual cortex that outperforms existing models in statistical accuracy and biological plausibility.

This study investigates the role of Odd-skipped in Drosophila CNS development, showing it regulates neurite morphology, affects cell survival, and influences synaptic formation and neural function.

The paper investigates how growth cones navigate microtubule-dependent stepwise advance on laminin-1 by testing the role of actin protrusions and microtubule entry.

The paper identifies FGF signaling as essential for myotube guidance during Drosophila myogenesis by regulating actin cytoskeleton dynamics through Rho/Rac GTPases.

This study shows CRMP2 is essential for Sema3F-dependent axon pruning and dendritic spine remodeling, linking its dysfunction to ASD-like behaviors in mice.

The paper shows that CTBP-1 represses SAX-7/L1CAM to regulate SMD motor neuron axon development, with LAD-2 acting as a parallel factor in axon guidance.

The paper shows that Drosophila adult muscle precursor cells guide motor axon pathfinding and proper muscle innervation through dynamic interactions with motor neurons.

The paper identifies SAX-7 and GRDN-1 as essential for dendrite development through retrograde extension in C. elegans neurons.

This study investigates the role of the diencephalon in guiding thalamocortical axons in mice, finding that molecular cues in the thalamus are critical for proper topographic mapping.

This study identifies a gradient-independent role of Wnt signaling in stereotyped neurite pruning in C. elegans motor neurons.

This study identifies Robo2 as a synaptogenic molecule critical for excitatory synapse formation and spatial coding in hippocampal circuits.

The paper quantifies the long-range attractive signal for Drosophila germ cell migration mediated by Hmgcr, showing it operates independently of Hh and is aided by Wunens.

The paper identifies modular transcriptional programs that independently control dendritic and axonal connectivity in Drosophila T4/T5 neurons.

This study shows Retinoic Acid regulates Hgf/Met signaling dynamics to organize the vagus motor topographic map in zebrafish.

This study shows RACK1 is required for BDNF-induced local translation of β-actin mRNA at growth cone point contacts, which regulates axon guidance and development.

The paper shows that embryonic chick ganglia explants exhibit asymmetric neurite outgrowth with co-orientation between neighboring explants, suggesting a potential community effect in neuronal development.

The paper investigates how spiral ganglion neurons navigate through the cochlea by interacting with glia and other cellular structures to form ordered connections with hair cells.

This study shows that ephrin-A5 enhances Neogenin availability at growth cones, potentiating netrin-1 axon guidance in LMC neurons.

This study shows that Slit/Robo signals are necessary for maintaining spinal motor neurons within the neural tube by organizing the basement membrane.

The paper develops a 4D analysis method and computational model to show that filopodia compete for synaptic seeding factors, leading to serial synapse formation in Drosophila R7 photoreceptor axons.