Renal and related cancers

The paper shows geometric effects concentrate WNT9b at branch junctions during kidney development, positioning renal vesicles.

This study identifies netrin-1 as a regulator of vascular patterning in kidney development, showing its role in arterial formation and mural cell differentiation through the Ntn1-Klf4 axis.

This study shows that Netrin-1 from stromal progenitors in the developing kidney is essential for vascular patterning and maturity, as its deletion leads to hypoplastic kidneys with altered vascular features.

This study identifies Ssbp2 as a cofactor of the Ldb1-Lhx1 complex required for Xenopus pronephros morphogenesis and differentiation.

The paper identifies renal interstitial cells (RICs) as key providers of a microenvironment for nephron regeneration in zebrafish, showing they secrete PGE2 to promote progenitor cell proliferation and nephron maturation.

The paper shows how mouse embryonic kidney epithelium resolves geometric packing conflicts through internally generated tensions to avoid defects.

This study shows that FGF8 promotes nephron progenitor survival by regulating BAX/BAK-mediated apoptosis, partially rescuing kidney development in Fgf8 mutants.

The paper identifies a distal enhancer, CNS1, that drives Hnf1b renal expression and is responsive to Pax8 in Xenopus and mammalian renal cells.

This study shows FGF8 promotes chemokinesis in mouse nephron progenitor cells, facilitating their condensation around ureteric buds.

The paper uses single-cell chromatin accessibility and gene expression data to study regulatory dynamics in mouse nephron progenitors, identifying cell-type-specific cis-regulatory elements and transcription factors involved in fate decisions.

The paper characterizes chromatin accessibility and microRNA expression in nephron progenitor cells during kidney development, identifying changes in regulatory elements and microRNAs associated with key biological processes.

This study shows that Tshz3 haploinsufficiency in mice causes kidney structural, molecular, and functional abnormalities.

This paper uses a Cellular Potts Model to simulate cell movement and aggregation during kidney development, showing that chemoattractant secretion and cell adhesion differences drive NP cell patterning.

This study uses single-cell RNA sequencing to identify differential cell cycle activity in nephron progenitors during mouse kidney development, highlighting Birc5 as a potential key molecule in nephron patterning.

The paper shows age-dependent changes in nephron progenitor translation and signaling that influence nephrogenesis timing, with Tsc1 affecting Wnt signaling balance.

The paper shows that osr1 regulates intermediate mesoderm formation and delays vessel progenitor differentiation in zebrafish.

This paper maps the 3D dynamics of the extracellular matrix during murine kidney development, identifying transient changes in interstitial matrix proteins and their spatial organization.

This study evaluates the growth of transplanted metanephros in rats using imaging and finds that optimizing urinary tract reconstruction timing reduces fibrosis.

This study shows that Kctd15 paralogs restrict distal nephron segment development by repressing Tfap2a activity in zebrafish.

This study shows Hnf4a is essential for Cdh6-expressing progenitors to develop into proximal tubules in the mouse kidney by regulating genes involved in reabsorption.

This study identifies Sprouty1's role in regulating FGF signaling to maintain nephron progenitors, showing that Spry1 haploinsufficiency rescues renal agenesis and progenitor depletion caused by Fgf9/Fgf20 loss.

This study shows that asynchronous mixing of kidney progenitor cells in organoids enhances nephrogenesis and functional features, but stromal overgrowth limits long-term study.

The paper identifies Fzd5, Lrp6, and Rspon1 as critical components required for WNT9b responsiveness in nephron progenitor cells.

This study shows that Dnmbp is essential for nephrogenesis in Xenopus laevis, with knockdown and overexpression leading to developmental defects in kidney structures.

The paper uses single-cell RNA-seq to analyze developing mouse kidney and human kidney organoids, identifying cell clusters and revealing insights into kidney development and organoid maturation.

The paper examines the chromatin landscape of nephron progenitors across age, identifying age-related changes in chromatin accessibility and regulatory regions that suggest old progenitors are epigenetically primed for differentiation.

This study identifies tfap2a as a key regulator of distal nephron segment differentiation in zebrafish, revealing its role in controlling gene regulatory networks and specialized metabolic functions.

This study uses single-cell transcriptomics to analyze human fetal kidney development, identifying 17 cell clusters and their lineage trajectories.

This study uses light sheet fluorescence microscopy to track cell fate and morphological development in kidney organoids over 15 hours.