Author
Louis S. Prahl
University of PennsylvaniaORCID 0000-0002-7811-6041Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 22 mutual co-author links5 papers
Recent·Most cited
- Developmental BiologyNature CommunicationsPeer-reviewed
Engineering kidney developmental trajectory using culture boundary conditions
Aria Zheyuan Huang, Louis S. Prahl, Karen L. Xu…·Alex J. Hughes
This paper develops a 3D culture technique to study kidney development and shows that matrix stiffness and adhesion influence nephron formation and spacing.
3 citations - BioengineeringProceedings of the National Academy of SciencesPeer-reviewed
Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation
Jiageng Liu, Louis S. Prahl, Aria Zheyuan Huang, Alex J. Hughes
MATCHY quantifies cell adhesion and traction in primary kidney cells, revealing an energetic ratchet mechanism driving nephron condensation during differentiation.
- BioengineeringbioRxivPreprint
Rho/ROCK activity tunes cell compartment segregation and differentiation in nephron-forming niches
John M. Viola, Jia‐Geng Liu, Aria Zheyuan Huang…·Alex J. Hughes
This study shows that Rho/ROCK inhibition enhances mixing between nephron progenitor and stromal cells, increasing nephrogenesis in kidney organoids.
- Developmental BiologyDevelopmental CellPeer-reviewed
The developing kidney actively negotiates geometric packing conflicts to avoid defects
Louis S. Prahl, John M. Viola, Jiageng Liu, Alex J. Hughes
The paper shows how mouse embryonic kidney epithelium resolves geometric packing conflicts through internally generated tensions to avoid defects.
20 citations