Renal and related cancers

This paper identifies genetic variants and transcription factors associated with unilateral renal agenesis in rats, suggesting a threshold mechanism involving KIT and interacting transcription factors.

The paper investigates the role of canonical Wnt transcriptional complexes in nephron progenitor cell regulation, finding distinct roles in induction versus maintenance of nephrogenesis.

This study identifies Hedgehog signaling as critical for maintaining mesenchymal nephron progenitors by inhibiting Notch signaling and upregulating Fox factors.

This paper develops a synthetic niche to expand nephron progenitor cells, enabling organoid generation and CRISPR screening for kidney development and disease.

This study creates an interactive atlas of human fetal kidney development using electron microscopy, identifying new stages and cellular dynamics in nephrogenesis.

The paper identifies renal interstitial cells (RICs) as key providers of a microenvironment for nephron regeneration in zebrafish, showing they secrete PGE2 to promote progenitor cell proliferation and nephron maturation.

The paper shows how mouse embryonic kidney epithelium resolves geometric packing conflicts through internally generated tensions to avoid defects.

This study shows that FGF8 promotes nephron progenitor survival by regulating BAX/BAK-mediated apoptosis, partially rescuing kidney development in Fgf8 mutants.

The paper identifies a distal enhancer, CNS1, that drives Hnf1b renal expression and is responsive to Pax8 in Xenopus and mammalian renal cells.

This study shows FGF8 promotes chemokinesis in mouse nephron progenitor cells, facilitating their condensation around ureteric buds.

This study shows fibronectin regulates metanephric kidney development by influencing branching morphogenesis and glomerulogenesis in mice and humans.

This study shows that interstitial Notch signaling regulates proximal tubule development in mouse kidneys through the Gata3-Renin axis.

The paper uses single-cell chromatin accessibility and gene expression data to study regulatory dynamics in mouse nephron progenitors, identifying cell-type-specific cis-regulatory elements and transcription factors involved in fate decisions.

The paper characterizes chromatin accessibility and microRNA expression in nephron progenitor cells during kidney development, identifying changes in regulatory elements and microRNAs associated with key biological processes.

This study shows that Tshz3 haploinsufficiency in mice causes kidney structural, molecular, and functional abnormalities.

The paper investigates Notch signaling's role in nephron segmentation, finding it promotes proximal fate selection while not affecting distal fate in mouse and human kidney development.

This paper uses a Cellular Potts Model to simulate cell movement and aggregation during kidney development, showing that chemoattractant secretion and cell adhesion differences drive NP cell patterning.

This study uses single-cell RNA sequencing to identify differential cell cycle activity in nephron progenitors during mouse kidney development, highlighting Birc5 as a potential key molecule in nephron patterning.

The paper shows age-dependent changes in nephron progenitor translation and signaling that influence nephrogenesis timing, with Tsc1 affecting Wnt signaling balance.

The paper identifies the MAPK/ERK pathway as critical for nephron progenitor metabolism, showing its role in energy and nucleotide biosynthesis, glycolysis, and proline metabolism.

The paper shows that osr1 regulates intermediate mesoderm formation and delays vessel progenitor differentiation in zebrafish.

This paper maps the 3D dynamics of the extracellular matrix during murine kidney development, identifying transient changes in interstitial matrix proteins and their spatial organization.

This study shows that specific collagen XVIII isoforms regulate ureteric branching morphogenesis through their TSP1-like domain in kidney development.

This study evaluates the growth of transplanted metanephros in rats using imaging and finds that optimizing urinary tract reconstruction timing reduces fibrosis.

This study identifies Osr1's role in maintaining renal progenitors and regulating podocyte development through Wnt2ba expression, revealing its antagonistic relationship with Hand2.

This study shows that Kctd15 paralogs restrict distal nephron segment development by repressing Tfap2a activity in zebrafish.

This study shows Hnf4a is essential for Cdh6-expressing progenitors to develop into proximal tubules in the mouse kidney by regulating genes involved in reabsorption.

This study identifies Sprouty1's role in regulating FGF signaling to maintain nephron progenitors, showing that Spry1 haploinsufficiency rescues renal agenesis and progenitor depletion caused by Fgf9/Fgf20 loss.

This study shows that excess fetal GDNF can prolong nephrogenesis in postnatal mouse kidneys without increasing tumor risk.

This study shows that asynchronous mixing of kidney progenitor cells in organoids enhances nephrogenesis and functional features, but stromal overgrowth limits long-term study.