Leptospirosis research and findings

This study investigates Leptospira infection in hedgehogs in France, finding that 22% of tested individuals were positive, with L. interrogans SG5 and Australis serogroup as prevalent strains, and age and season as significant risk factors.

This study shows beta-lactam antibiotics induce a Jarisch-Herxheimer reaction in leptospirosis through TLR2/4 and TLR2/5-dependent mechanisms in mice and humans.

This study shows that pathogenic Leptospira uses glucose under host-like temperatures, contradicting previous assumptions about its metabolic capabilities.

This study identifies metabolites from the soil bacterium Massilia that promote Leptospira growth, revealing a metabolic interaction between environmental bacteria and a pathogen.

This paper develops a machine learning framework to classify Leptospira serogroups using genomic data, achieving high accuracy and offering a scalable alternative to traditional serological methods.

This study identifies glutamine as a key nitrogen source for Leptospira interrogans under physiological conditions and shows that targeting glutamine metabolism could inhibit bacterial proliferation and infection.

This study identifies LipL32 as a key structural protein in Leptospira interrogans that maintains cell-envelope integrity and stiffness, affecting pathogenicity.

The paper identifies sORFs in Leptospira interrogans that link DNA methylation to pathogenicity and adaptability through transcriptomic and network analysis.

This study characterizes the diadenylate cyclase CdaA in Leptospira interrogans, showing it produces c-di-AMP and its activity depends on specific divalent cations.

This study uses dual RNA-Seq to identify bacterial effectors that disrupt host cell junctions and enable Leptospira colonization by modulating calcium signaling.

This study compares TLR4-competent and hyporesponsive mouse strains to determine their susceptibility to leptospirosis, finding that TLR4 function is important but not sufficient for disease susceptibility.

This paper identifies DMEM and EMEM as better in vitro media for studying leptospiral pathogenesis compared to EMJH and HAN by mimicking host gene expression profiles.

The paper describes the structural and functional genomic composition of L. santarosai serovar Alice, identifying genomic features and comparing them to other Leptospira species.

The paper sequences and analyzes the genome of a Colombian Leptospira santarosai strain to identify virulence factors and core-genome characteristics.

The paper investigates leptospirosis transmission among brown rats in Boston, finding high genetic structure and limited dispersal, with Leptospira clades linked to specific rat populations and a human case linked to rats.

The paper identifies genetic patterns in the rfb locus of Leptospira species to propose molecular markers for serogroup classification.

The paper uses comparative genomics to analyze whole genome sequences of Leptospira spp., identifying virulence factors and reclassifying species based on genetic divergence.

The paper develops and validates an ELISA test using recombinant LipL32 protein for detecting canine leptospirosis, showing high reproducibility and concordance with PCR.