Enzyme function and inhibition

This paper presents the first cryo-EM structure of DAB2, revealing a PMF-driven CO2 hydration mechanism in chemolithoautotrophs.

The paper analyzes genomic and metagenomic data to identify novel carbonic anhydrase clades, their diversity, and biome-specific distribution across microbial taxa.

This study expresses carbonic anhydrase in Acinetobacter sp. Tol 5 to enhance CO2 conversion as a whole-cell biocatalyst, finding that periplasmic expression significantly improves activity.

The paper presents a unified enzyme kinetic model that integrates six inhibition mechanisms into a single framework, showing they are facets of the same model.

This study identifies βCA4 as a key gene involved in bicarbonate tolerance in Arabidopsis roots, showing its upregulation and associated physiological responses under bicarbonate stress.

The paper designs and tests novel covalent inhibitors targeting CAIX, achieving high affinity and selectivity for cancer treatment.

The study identifies CAH1, a periplasmic carbonic anhydrase in Chlamydomonas reinhardtii, as essential for maintaining high inorganic carbon affinity under CO2-limiting conditions.

This study investigates the role of specific amino acids in the cyanobacterial CO2 uptake complex NDH-14, focusing on their impact on Zn coordination and catalytic activity.

The paper identifies that CsoSCA, a carboxysomal carbonic anhydrase in cyanobacteria, is allosterically activated by RuBP, revealing a regulatory mechanism in CO2 fixation.