Psychedelics and Drug Studies

This study shows that a single intravenous dose of psilocybin reduces mechanical hypersensitivity in a rat model of chronic pain for 28 days but has limited effect on thermal hyperalgesia.

HADES framework analyzes spacetime activity patterns in the brain, showing reduced low-frequency harmonic modes during DMT-induced states, indicating changes in functional hierarchy.

The paper identifies 5-HT2A receptor signaling pathways that determine psychedelic potential using selective ligands and behavioral assays in mice.

This study shows that classic and dissociative psychedelics induce similar hyper-synchronous high-frequency oscillations in brain regions involved in cognition and emotion in rats.

This study uses TD-fNIRS to examine acute ketamine effects on brain dynamics and physiology in humans, finding changes in consciousness, brain connectivity, and potential biomarkers for mystical experiences and depression.

This review examines how psychedelic compounds affect neurogenesis and brain plasticity, finding varied effects across different classes of psychedelics.

This study examines how LSD and music affect brain dynamics using fMRI, finding changes in task-positive brain states and suggesting music's influence on resting-state activity.

This study examines how psilocybin and environment affect brain-wide immediate early gene expression in mice using c-Fos immunofluorescence and light sheet microscopy.

This study establishes dose-response relationships for LSD-induced subjective experiences using meta-analysis of psychometric data from validated questionnaires.

This study investigates LSD's effects on brain connectivity using fMRI and finds increased interregional connectivity and reduced self-inhibition, suggesting a disruption of the Excitation/Inhibition balance.

This study shows that psilocybin therapy increases low-frequency brain responses to music in patients with treatment-resistant depression, correlating with subjective drug effects.

This study examines how LSD microdosing affects time perception by reducing the influence of temporal priors.

This study shows that psilocin causes sex-specific, time-dependent changes in central amygdala reactivity and threat responses to aversive stimuli.

This study investigates the behavioral and neural effects of 5-MeO-DMT in mice, showing dose-dependent changes in behavior and long-term dendritic spine density increases without affecting spine size.

This study shows that LSD alters the effects of brain stimulation in rats, creating distinct changes in brain activity compared to stimulation alone after 24 hours.

This study shows that the psychedelic DOI induces persistent desynchronization in the medial prefrontal cortex of mice during rest and active states, altering neural activity patterns.

This study shows acute psilocybin improves cognitive flexibility in rats by enhancing switching between learned strategies, with effects mediated by 5HT2A receptors.

This study uses Ising models and algorithmic complexity to analyze fMRI data and finds LSD increases brain complexity and moves it further from criticality.

This study maps brain regions with drug-induced c-Fos expression after psilocybin and ketamine in mice, revealing shared and distinct patterns linked to glutamatergic receptors.

This study shows that 5-MeO-DMT induces a dissociated brain state in mice with features of both wakefulness and sleep, including slow waves and pupil dilation, while suppressing REM sleep.

This study investigates how LSD affects reinforcement learning in humans by examining changes in learning rates, reinforcement sensitivity, and exploratory behavior during a probabilistic reversal learning task.

This study investigates the role of 5-HT2A, 5-HT2C, 5-HT1A, and TAAR1 receptors in modulating head twitch response induced by 5-HTP and psilocybin in mice, showing their potential therapeutic relevance.

This study shows psilocin excites 5-HT2A Layer 5 Pyramidal Neurons in the mouse PFC via a Gq-mediated mechanism, increasing firing without affecting synaptic transmission.

This study shows that both canonical and non-canonical psychedelics induce similar changes in brain network connectivity in humans.

This paper shows that LSD and psilocybin reduce brain control energy and increase entropy by flattening the brain's energy landscape, using network control theory and PET data.

This study compares neural dynamics changes in schizophrenia and psychedelic-induced states using M/EEG data, finding distinct patterns in information transfer and Bayesian inference alterations.

This study examines psilocybin's effects on thalamic functional organization and connectivity using a novel ICA approach, revealing spatially constrained changes in intrathalamic nuclei and thalamocortical connections.

This study evaluates the behavioral and neurochemical effects of ten novel N-Benzyl-2-phenylethylamine derivatives in adult zebrafish, identifying compounds with hallucinogenic-like and anxiolytic properties.

The paper uses machine learning to analyze drug testimonials and link them to neurobiological and psychological effects, revealing distinct patterns associated with different substances.

This study shows that LSD and psilocybin reduce hierarchical cortical organization by flattening connectivity gradients, supporting a mechanistic model of the psychedelic state.