Amino Acid Enzymes and Metabolism

This paper identifies high-affinity inhibitors of B0AT1 and elucidates their mechanism of action through cryo-EM structures.

This study identifies SLC17A1 and SLC17A3 as key transporters for Lac-Phe excretion in urine, showing genetic and functional associations in mice and humans.

This study identifies SLC7A11 as a mediator of cisplatin resistance in cancer cells and shows asparaginase therapy can target this resistance.

The paper traces the evolutionary history of aminotransferases across species, revealing their substrate promiscuity and how it shaped nitrogen metabolic networks.

The paper investigates how changes in large neutral amino acid metabolism during development affect neuronal excitability and survival, finding that Slc7a5 deletion disrupts lipid metabolism and leads to long-term circuit dysfunction.

The paper compares L-lysine and L-arginine biosynthesis pathways in 23 Deinococcus genomes, identifying structural variations and potential functional divergence.

This study reports cryo-EM structures of human EAAT2 in substrate-free and inhibitor-bound states, revealing structural features and the mechanism of selective inhibition.

The paper determines the structure of GlyT1 bound to an inhibitor, revealing its mechanism of non-competitive inhibition and informing drug design.

The paper develops a computational model to simulate amino acid translocation and demonstrates its ability to predict cytosolic concentrations in cancer cell lines and myotubes.

The paper investigates strategies to induce serine synthesis genes through dietary and pharmacological interventions, finding that low protein and ketogenic diets, as well as certain medications, increase their expression in the liver and brain.

This study identifies SorCS2 as a regulator of EAAT3 trafficking that protects neurons from oxidative stress and epilepsy-induced damage.