Shuke Xiao

This study identifies MCT6 as an intestinal exporter of Lac-Phe, showing its role in metformin-induced weight loss and systemic metabolite regulation.

The paper identifies a conserved postprandial metabolite, pTOS, that links nutrient intake to energy balance through a gut-brain pathway in pythons and mice, with potential relevance to humans.

This study identifies a PTER inhibitor that reduces food intake and body weight in mice, linking PTER function to obesity treatment.

The paper identifies PIEZO2 as a key mechanosensitive ion channel in adipose sensory innervation and shows its role in regulating adipose tissue phenotypes.

This study identifies SLC17A1 and SLC17A3 as key transporters for Lac-Phe excretion in urine, showing genetic and functional associations in mice and humans.

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.