Planarian Biology and Electrostimulation

This study identifies genetic factors that specify dopaminergic neuron identity and location during planarian regeneration, showing combinatorial mechanisms guide both neurotransmitter choice and regional placement.

This study identifies Wnt/β-catenin signaling as a key factor in promoting posterior axial regeneration in non-regenerative tail fragments of the annelid Capitella teleta.

This study uses scRNA-seq to investigate cell type allometry in planarians, finding that gut basal cells respond most to size changes.

The paper shows that Planar Cell Polarity (PCP) signaling regulates stem cell division symmetry to control termination of adult tissue regeneration in planarians.

The paper uses a novel transgenic reporter to study epigenetic reprogramming during zebrafish fin regeneration, identifying early chromatin remodeling events and key factors required for regeneration.

The paper identifies RoboA and Anosmin-1 as regulators of cell fate in planarian stem cells, showing their role in maintaining organ regeneration fidelity.

This study shows that mechanical properties and YAP/TAZ activity influence position-dependent cell proliferation during axolotl limb regeneration.

Regeneration in aging planarians reverses age-related physiological and molecular changes, restoring youthful gene expression and tissue composition.

This study shows connective-tissue cells are essential for axolotl limb regeneration, making up 75% of blastema cells and requiring specific signaling for regeneration.

The paper investigates excessive chondrogenesis in Xenopus froglet blastemas during limb regeneration, finding it initiates at the medium bud stage and progresses spatially and temporally.

This study investigates planarian light-sensing strategies, revealing their ability to use both spatial and temporal light information for navigation and orientation.

This study uses high-resolution imaging to analyze neuronal and muscle structures in planarians during growth and regeneration, revealing patterns and responses to genetic perturbations.

This study identifies map3k1 as a suppressor of terminal differentiation in planarian eye regeneration, showing its role in maintaining progenitors in an undifferentiated state during migration.

This study uses multi-omics analysis of Polypterus fin regeneration to identify shared and divergent mechanisms with limb regeneration.

This study identifies distinct wound closure strategies in the acoel Hofstenia miamia, revealing novel heterotypic cellular bridges and the role of actomyosin contractility in regeneration.

This study shows that whole-body regeneration in a flatworm occurs without conventional neoblasts, challenging the idea that neoblasts are essential for regeneration.

This study shows that reactive oxygen species (ROS) are essential for regeneration in the annelid Lumbriculus variegatus, as inhibiting ROS delayed regeneration and exogenous ROS partially rescued it.

This study identifies gene gain and regulatory shifts in terrestrial planarians as key mechanisms for terrestrialization, showing distinct stress response toolkits compared to freshwater relatives.

This study compares toxin and mucus protein evolution in aquatic and terrestrial flatworms, finding broader toxin gene repertoires and distinct functional expansions in terrestrial species.

This study identifies two TRPMs in planarians, showing Smed-TRPM-c is essential for spermatogenesis and germline stem cell maintenance.

This study identifies Neuregulin-ErbB signaling from muscle as essential for mobilizing stem cells during whole-body regeneration in Hofstenia miamia.

This study identifies a spreading ERK signaling signal from muscle cells that drives regeneration in the acoel Hofstenia miamia.

The paper investigates regenerative versus non-regenerative outcomes after mouse digit amputation by analyzing the wound bed's transcriptomic landscape and immune microenvironment, identifying key transcription factors and developing a predictive AI model.

This study investigates planarian regeneration specificity by examining the role of the cWnt signalling gradient in head and tail formation across two species.

The paper maps cellular profiles and lineage restrictions during posterior regeneration in Platynereis dumerilii using single-cell RNA sequencing and mosaic transgenesis, revealing molecular parallels with vertebrate regeneration.

This study investigates gill regeneration in mayflies, identifying conserved molecular pathways across insects.

The paper shows Mest expression in mouse digit regeneration is regulated by promoter switching, not imprinting, and modulates neutrophil response.

This study shows planarians develop radiotolerance through repeated ionizing radiation exposure, maintaining genomic integrity and reproductive function.

This paper develops a toolkit for live imaging of whole-body regeneration in flatworms, revealing neuron regenerative limitations and independent nerve cord reconnection.

The paper identifies injury-induced transcription in planarian outer epithelium critical for regeneration and highlights a conserved gene involved in the process.