Planarian Biology and Electrostimulation

This study characterizes the reproductive anatomy, development, regeneration, and behavior of the acoel worm Hofstenia miamia, revealing size-dependent growth rules and long-term sperm storage and self-fertilization capabilities.

The paper develops a hybrid agent-based model to simulate limb blastema formation, identifying epithelial softening and Wnt signaling as key factors in regeneration.

This study evaluates the use of planarians as a model for detecting seizurogenic chemicals, showing that several mammalian seizurogens induce seizure-like behavior in two planarian species.

This paper develops and compares two cell-ablation systems in axolotls to study macrophage roles in regeneration, finding macrophages are essential for skeletal and nervous system repair.

This study shows that map3k1 is essential for restricting progenitor differentiation to specific locations in planarians, preventing ectopic differentiation and tumor formation.

This study shows that dorsoventral contact is necessary for Shh induction in axolotl limb regeneration, with dorsal and ventral signals driving pattern formation.

The paper identifies injury-induced electrochemical coupling between tissue depolarization and intracellular signaling as essential for organ regeneration in zebrafish.

This study shows that Capitella teleta larvae can regenerate lost structures only after metamorphosis into juveniles, suggesting metamorphosis enables regeneration.

The paper investigates how soxB1-2 influences chromatin dynamics and gene expression during planarian neurogenesis using ATAC-seq and RNA-seq.

This study uses single-cell RNA sequencing to identify fibroblast subpopulations and genes linked to fibrosis and regeneration, then tests their effects using AAV gene delivery in mouse digits.

This study constructs a 4D spatiotemporal transcriptomic map of planarian regeneration using Stereo-seq, identifying dynamic gradients and an injury-induced regenerative zone.

The paper shows that activin/TGF-beta signaling inhibits regeneration after radiation in planarians, but its depletion restores regeneration by increasing stem cell proliferation despite DNA damage.

The paper identifies molecular differences between regenerating blastema and non-regenerating CSD in axolotl limbs and uses Wnt3a expression to induce cartilage bridging in CSD.

This study shows that regeneration potential varies along the anterior-posterior axis in Capitella teleta, with posterior fragments regenerating more completely than anterior ones.

This study investigates FGF signaling's role in caudal regeneration in the annelid Alitta virens, finding it essential for blastema induction but not posteriorization, with conserved mesodermal patterning functions.

The paper identifies voltage-gated calcium channels as regulators of zebrafish fin regeneration, showing their role in controlling outgrowth scale through Ca2+ fluxes.

This paper describes a protocol for using RNA interference in planarian embryos to study gene function during regeneration.

This study identifies Smed-pou4-2 as a regulator of mechanosensory neuron regeneration and function in planarians, showing its role in maintaining sensory identity and behavior.

This study shows that memory capability persists after neuronal regeneration in planarians but memory quality decreases following oxidative stress-induced neuronal damage.

This paper shows that adrenergic signaling coordinates systemic and local stem cell activation after amputation in axolotls, enhancing regeneration.

The paper shows that Gram-positive skin bacteria and Tlr2 signaling influence tail regeneration in Xenopus laevis tadpoles by promoting regenerative programs over wound healing.

This study identifies head-derived signals that regulate regeneration competence in Hymenolepis diminuta by balancing pro- and anti-regeneration cues from the germinative region.

The paper compares regeneration of two complex structures in Platynereis, finding shared and distinct molecular, cellular, and morphological features in their regenerative processes.

The paper describes a spontaneous developmental error in flatworms leading to double-headed worms with reversed body axis polarity, which can regenerate normally.

This study identifies TIP60 as essential for wound response in planarians through its role in stem cell maintenance and regeneration.

The paper identifies ddx43+ cells as regulators of slow-cycling neoblasts in planaria using single-cell transcriptomics and functional analyses.

This study identifies a parenchymal niche composed of abracada cells that regulate pluripotent stem cell function and regeneration in planarians.

This study investigates how adhesion and injury cues influence the predation of blackworms by planarians, showing that adhesion prevents escape and injury cues may signal prey.

The paper shows that Fgf induces ECM degradation via Mmps expression in frogs, promoting joint regeneration through BMP secretion and blastema cell activity.