Planarian Biology and Electrostimulation

The paper investigates the cellular processes between HIF-1 activation and G2 arrest in MRL mouse regeneration, identifying EMT and chromatin remodeling as key intermediaries.

This study assesses the regenerative potential of annelid larvae, finding they complete early but not late stages of regeneration and can metamorphose into juveniles.

The paper develops a simplified and faster in situ hybridization protocol for planarians, reducing steps and hands-on time while maintaining staining quality.

This study identifies PCP pathway components, pk-1 and dgo-1, as essential for anterior and posterior regeneration in Hofstenia miamia, with pk-1 affecting muscle organization and gene expression in tail fragments.

The paper generates a high-quality reference transcriptome for Platynereis dumerilii and analyzes RNA-seq data from posterior regeneration stages to identify gene expression dynamics and key molecular mechanisms.

The paper investigates Wnt and Hedgehog signaling in tapeworm segmentation, finding that segments form through secondary AP axes linked to neuromuscular systems and regeneration mechanisms.

This study shows that BMP signaling suppresses Wnt signals to integrate anteroposterior and mediolateral patterning in adult planarians, revealing integrated axis control during regeneration.

The paper identifies key genes involved in regeneration in axolotl limbs by comparing transcriptomic data from juvenile and aged axolotls.

This study identifies Ets-1 as a regulator of glial cell regeneration and function in planarians, revealing its role in maintaining nervous system architecture and behavior.

The paper investigates limb regeneration in ladybird beetles, finding that blastema formation is essential for regeneration, as amputation without blastema cells prevents limb redevelopment.

The paper shows that injury triggers ultrafast Erk signal propagation in planarians, mediated by body-wall muscles, which is essential for regeneration.

This study identifies Regeneration Initiating Cells (RICs) in Xenopus laevis tail regeneration using single cell and spatial transcriptomics, showing their role in initiating regeneration by modifying the extracellular matrix.

This study identifies Egr-2 as a regulator of intestinal remodeling and pharynx regeneration in planarians, showing its role in midline patterning and tissue integration.

This study identifies seven heterotrimeric G protein subunits that promote planarian regeneration and two subunits critical for anterior polarity re-establishment, while also finding five G proteins modulate behavior.

The paper identifies FoxG as an upstream regulator of wnt1 involved in posterior identity specification during planarian regeneration through genomic analyses.

The paper proposes a conceptual and computational framework for regeneration of form and function in biological organisms, demonstrating its ability to restore anatomical and bioelectric homeostasis in an in silico model.

The paper shows that nail tissue, not dorsoventral polarity, is essential for digit tip regeneration, and identifies Lmx1b's role in this process through transcriptomic analysis.

This study shows that brain hormones, specifically methylfarnesoate, are essential for posterior regeneration in Platynereis dumerilii, and their absence after decapitation impairs regeneration.

This paper replicates and refutes a claim that dietary supplements induce leg regeneration in Drosophila, finding no evidence of regeneration or regeneration-like structures.

PLANAtools provides an interactive repository for analyzing planarian gene expression data from over 160 studies, enabling users to generate plots and annotations without requiring advanced computational expertise.

The paper identifies a muscle midline signaling center regulated by dorsoventral Netrins and Bambi-2 in planarians, which controls blastema formation during regeneration.

The paper uses high-throughput expression profiling and RNAi screening to identify novel regulators of planarian neoblast stem cells.

The paper shows that regenerated crustacean legs in Parhyale precisely replicate the microanatomy, sensory function, and transcriptional profiles of uninjured legs.

The paper identifies enhancer-like elements in planarian adult stem cells using epigenetic and expression data, and links them to regulatory networks involved in regeneration.

This study identifies two fibrillarin homologs in planarians and shows their distinct roles in cell lineage development and tissue regeneration.

This study shows that Klf4 is essential for germline and yolk cell development and regeneration from somatic stem cells in planarians.

This study identifies two intestine-enriched apolipoprotein b orthologs in planarians that are essential for stem cell differentiation and regeneration by transporting lipids to target tissues.

This study compares gene expression dynamics during leg development and regeneration in Parhyale hawaiensis, finding distinct temporal patterns despite shared gene sets.

This paper characterizes a new planarian isolate, Girardia sp. (Guanajuato), at morphological, cellular, and molecular levels to identify unique traits and facilitate future comparisons.

This study shows that reactive oxygen species (ROS) signaling differentially controls wound healing and regeneration in planarians by regulating distinct downstream targets.