Planarian Biology and Electrostimulation

Electric stimulation restores DNA integrity and cell cycle in planarian tissues damaged by ionizing radiation through Ca2+ signaling and stem cell activation.

The paper identifies dynamic stem cell microenvironments in planarians that support regeneration by associating with diverse cell types.

This study identifies Src-1 as a factor that promotes robustness in planarian anteroposterior axis patterning by restricting head and trunk identities to anterior positions.

The paper identifies Tig1 as a regulator of proximo-distal identity during salamander limb regeneration through single-cell RNAseq analysis.

The paper identifies genes and factors involved in female germ cell development and regeneration in planarians, revealing shared molecular signatures with pluripotent stem cells and distinct somatic roles.

This study shows that the Xenopus laevis tadpole microbiome and lipopolysaccharide signaling influence tail regeneration outcomes, with TLR4 playing a partial role.

The paper characterizes stem cell dynamics and heterogeneity in the acoel Hofstenia miamia using single-cell transcriptomics, revealing lineage-primed neoblast subpopulations and their response to regeneration.

The paper identifies critical RING/U-box E3 ubiquitin ligases involved in planarian tissue regeneration through RNAi screening and functional analysis.

The paper investigates how variable Shh and Fgf8 positioning in axolotl limb blastemas ensures consistent limb morphogenesis across different sizes.

The paper shows that cell cycle arrest is necessary for stem cell differentiation in planarians, as inhibiting Cdh1 disrupts tissue homeostasis and regeneration.

This study identifies Hox gene functions in adult tissue segmentation and asexual reproduction in planarians, showing distinct roles for hox3 and post2b.

This study identifies that limb nerves provide essential cues for regulating the final size of regenerating axolotl limbs during the 'tiny-limb' stage.

The paper introduces a new fixation protocol for immunohistology and in situ hybridization in planarians that preserves tissue structure and allows for successful signal development.

This paper develops a transgenesis protocol for Hofstenia miamia, enabling stable transgene integration and tissue-specific fluorescent expression, revealing new insights into regeneration and cell biology.

The paper shows that bacteria are necessary for initiating tadpole tail regeneration by activating TLR pathways and sustaining NF-κB activity, which drives ROS production and regeneration.

This study shows that Pde4b regulates cellular differentiation during limb regeneration in urodele amphibians by modulating B2FF-induced plasticity in dermal fibroblasts.

This study investigates memory retention and transfer of addictive behavior in planaria, finding that addiction persists in both brain-containing and brainless posterior segments.

This study shows that m6A-mediated cell-cell communication is essential for planarian regeneration, as disrupting m6A methyltransferase leads to regeneration failure.

This study identifies TRiC's role in maintaining stem cell function during planarian starvation by activating the UPR and regulating energy and lipid metabolism.

This paper develops a mathematical model to explain planarian regeneration by incorporating positional control genes and wnt-related signaling gradients, showing improved polarity preservation in regeneration.

This study shows planarian stem cells adjust their behavior based on missing tissue type, with pharynx regeneration requiring specific proliferation and ERK signaling, while eye regeneration does not.

The paper identifies extrinsic cues from chondrogenic progression that inhibit AER cell formation and limit limb regeneration in Xenopus tadpoles.

This study shows apoptosis and Wnt signaling are required for regeneration and homeostatic growth in Ciona, with apoptosis promoting progenitor cell survival.

The paper generates a transgenic axolotl line expressing FUCCI to study cell cycle dynamics during tissue regeneration.

This study identifies and functionally characterizes five CBP genes in planarians, showing their roles in stem cell maintenance and differentiation.

The paper identifies two planarian CBP family members, CBP2 and CBP3, with distinct roles in stem cell maintenance and function.

This study identifies DDX24 as essential for planarian head regeneration by regulating muscle organization, pole specification, and Wnt signaling.

This study shows that ERK inhibition delays regeneration in headless planarians, but headless animals can later remodel to regain a single-headed morphology through Wnt/β-catenin signaling.

The paper identifies hydrogen peroxide as an upstream signal initiating planarian regeneration by activating pERK and linking it to EGFR-MAPK/ERK pathway activation.