Pharmacological Receptor Mechanisms and Effects

This study shows ibogaine induces metabolic preconditioning in neurons, enhancing synaptic plasticity and neural repair through transient metabolic stress and sigma-2 receptor activation.

Across 12 µs of all-atom simulations, cholesterol stabilizes the sigma-1 receptor trimer, while haloperidol, unlike (+)-pentazocine, engages β6-strand W136 to tighten interprotomer coupling.

This study shows that Sigma-1 receptor promotes glycolysis in neuronal systems by suppressing GRIM19, affecting NAD+/NADH metabolism and mitochondrial activity.

This paper characterizes the cyanobacterial metabolite Veraguamide E, showing it binds the sigma-2 receptor with high affinity, modulates calcium signaling in neurons, and lacks cytotoxicity.

This study shows that activating sigma-1 receptors with PRE-084 rescues synaptic plasticity and memory impairments caused by amyloid-beta oligomers in an Alzheimer's disease model.

This study investigates how sertraline affects hippocampal plasticity and learning through sigma 1 receptors, cellular stress, and neurosteroids in rat models.

This study investigates how sigma receptor ligands modulate cytosolic calcium levels in BV2 microglia cells, finding increased calcium levels and extracellular calcium entry with certain ligands.

The paper introduces a new model, BEST, to detect differences in drug effects on cocaine consumption, finding it more sensitive than existing models in certain contexts.

This paper identifies FEM-1689 as a σ2R/TMEM97 ligand that alleviates neuropathic pain by inhibiting the integrated stress response in mice and human sensory neurons.

This study develops a specific antibody and Cre-dependent conditional KO mouse to detect and delete the Sigma-1 receptor in specific cell types in vivo, revealing its widespread expression in neurons and glial cells.