Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology

Pharmacological Receptor Mechanisms and Effects

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Pharmacology & Toxicology·Journal of Chemical Information and ModelingPeer-reviewed·Jun 1, 2026
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MD simulations of Human Sigma1 Receptor Trimer Uncovers Cholesterol Dependent Stabilization and Ligand Specific Dynamics
Vittoria Nanna, Costanza Paternoster, Alessio Bartocci…+4 more authors·Giuseppe Felice Mangiatordi
Across 12 µs of all-atom simulations, cholesterol stabilizes the sigma-1 receptor trimer, while haloperidol, unlike (+)-pentazocine, engages β6-strand W136 to tighten interprotomer coupling.
2 citations
human·protein structure
·𝕏 Post·Bluesky