Discover, rate, and discuss biology preprints.

The paper introduces a high-throughput culturing platform with real-time metabolic profiling to study cellular metabolism and mitochondrial dysfunction.

This study shows that culturing primary melanocytes on nanoparticle substrates reduces focal adhesions and increases stemness gene expression while decreasing differentiation markers.

This paper improves anaerobic digestion models by integrating metaproteomics data to better represent microbial functions and dynamics in a two-step digester system.

This study identifies a combination of adjuvants that enhance the immunogenicity of naked mRNA vaccines delivered by jet-injection, achieving protection against SARS-CoV-2 and influenza with reduced reactogenicity.

This paper develops an iterative epitope-expansion strategy to design IgE-binding miniproteins targeting the FcεRI interface, improving affinity and validating structural models through experimental testing.

This study develops a photoresponsive synthetic basement membrane to investigate injury and repair processes in epithelial cells, finding that critical injury sizes lead to dysregulated re-epithelialization.

This paper demonstrates that DNA nanocages delivering aspirin reduce excitotoxicity and promote neuroprotection in zebrafish models of ischemic stroke.

This paper presents an automated microfluidic platform for generating large, precisely-defined lipid nanoparticle libraries and evaluates their physicochemical and transfection properties.

CellTrap enables long-term, single-cell analysis of immune-cancer interactions by controlling effector-to-target ratios, showing enhanced immune activity with higher ratios.

This paper develops a genetically engineered EV platform that increases yield and eliminates toxicity, enabling safe high-dose systemic delivery.

This paper develops a microfluidic device called LARLM for producing uniform lipid nanoparticles (LNPs) with high productivity and demonstrates improved bioavailability of loaded drugs in vitro.

This paper demonstrates that using affinity cocktails of antibody-radioconjugates improves tumor irradiation by combining high- and low-affinity variants to target different tumor regions, leading to better treatment outcomes.

This study incorporates the AcChiA chitinase protein into AcMNPV occlusion bodies, enhancing oral infectivity and larval mortality in bioassays.

This paper examines how proxy measurements in magnetic resonance spectroscopy affect statistical test outcomes, showing inflated false positive and negative rates due to bias and correlation with gold-standard measurements.

The paper designs protein-based inhibitors to efficiently inhibit and remove chymosin from whey, enabling sustainable cheese production and enzyme control.

The paper introduces a Cro/OR3 binary system for targeted gene expression in zebrafish and human cells, demonstrating its utility in manipulating specific cell types and studying biological processes.

This paper demonstrates efficient and durable gene activation using Cas9-mediated epigenome editing in a mouse model of LAMA2-CMD, showing sustained therapeutic effects beyond one year.

This study shows that mitochondria-containing large extracellular vesicles (lEVs) improve mitochondrial function in heat-stressed neurons and deliver mitochondria to motor neurons in vivo.

This study develops a discrete viscoelastic model to simulate immune cell migration through confined microchannels, showing how cellular stiffness affects migration efficiency.

This paper develops a 3D cancer-stromal tissue model using collagen microfibers to study THP-1 cell differentiation into macrophages and drug response in a tumor microenvironment.