Discover, rate, and discuss biology preprints.

This study develops a method to quantify subtendon sliding in the Achilles tendon using ultrasound and electrical stimulation, finding differential displacement patterns based on stimulated muscle.

This paper develops an in vivo method to covalently link peptide drugs to native IgGs, demonstrating sustained weight loss and glucose management with GLP-1.

This study shows that reducing flight time during running lowers tibial-fibular strains, suggesting grounded running may reduce stress fracture risk.

HybriSeq enables sensitive single-cell RNA profiling by combining in situ hybridization, split-pool barcoding, and sequencing to detect transcripts without end bias.

This paper computationally designs soluble CCR8 analogues that retain native antibody binding, achieving a 62% success rate with preserved structural and functional properties.

Protpardelle-1c is a protein structure generative model that improves motif scaffolding and multi-chain complex generation, achieving higher scores and faster sampling than existing models.

This study examines how changes in collagen gel elasticity and fibril density affect cell adhesion, showing opposing effects when both parameters increase.

This study develops a biocompatible polymeric resin for dental adhesion, showing improved bond strength and biocompatibility through triacrylate-trithiol crosslinking.

This paper introduces a phantom and analysis code to assess fluorescence uniformity and distortion in surgical imaging systems, finding that flat-field correction improves image appearance but may reduce quantitative accuracy.

The paper compares structural and compositional gradients across the dentin-enamel junction in human and mouse incisors, finding differences in density and mineral content gradients between species.

This study develops ECM-decorated biodegradable scaffolds as synthetic periosteal grafts, showing improved cell growth and angiogenic effects in vitro.

This study shows that norbornene homopolymerization limits cell spreading in thiol-ene hydrogels, and reducing norbornene density improves hydrogel relaxation and cell morphology.

This paper designs chimeric collagen-like proteins to create nanocomplexes for targeted doxorubicin delivery, showing enhanced tumor accumulation and reduced toxicity.

This paper introduces a label-free endoscopic platform combining Raman spectroscopy and OCT to track morphomolecular changes in real-time during carcinogenesis, enabling early cancer detection.

This study shows that a synthetic hydrogel enables crypt formation in intestinal organoids without exogenous laminin, revealing insights into mechanical and matricellular signaling.

This paper edits the ADA2 p.R169Q mutation in human hematopoietic stem cells using CRISPR-Cas9 and HDR, showing improved efficiency with NHEJ inhibitors but increased chromosomal deletions.

This study shows that personal lubricants can deliver the Human Contraception Antibody (HCA) effectively, with silicone-based formulations showing higher delivery efficiency.

This paper develops a mathematical model to predict site-specific cortical bone loss in mouse tibia under disuse conditions by relating stimulus loss to in-vivo bone loss data.

This study evaluates AlphaFold3's ability to predict antibody and nanobody structures and their docking with antigens, finding high accuracy but significant room for improvement.

This paper evaluates novel embolic agents using a vascularized liver tumor-on-a-chip model, finding that DESTH induces tumor cell death and alters cytokine levels and vascular morphology.