Kristi S. Anseth

This study investigates cardiac myofibril remodeling in Burmese pythons during digestion using multi-omics approaches, revealing post-translational modifications as key to increased contractility.

This study shows that strain-stiffening bottlebrush polymer hydrogels promote osteocyte-like differentiation and functional connectivity in hMSCs compared to collagen matrices.

This study shows that YAP and TAZ redundantly regulate muscle regeneration by controlling proliferation and migration of muscle stem cells, revealing genetic redundancy as essential for regenerative robustness.

This study shows that aged fibroblasts impair muscle stem cell self-renewal by depositing excessive fibronectin in a 3D hydrogel co-culture system.

The paper shows that fibrillar adhesions control nuclear mechanical response timescales through vimentin cytoskeleton anchoring via plectin 1f.

This study shows that the aged muscle tissue environment limits muscle stem cell function, and combined interventions can partially restore muscle mass in aged mice.

This study shows that activating FGFR1 restores Integrin-β1-mediated fibronectin sensing in aged satellite cells, improving their regenerative capacity.

This paper harmonizes 2D and 3D immunofluorescent cell shape datasets using generative AI to create synthetic cells for machine learning and in silico studies.

This study shows that nuclear mechanics influence intestinal stem cell differentiation by sensing tissue shape and modulating lamin-A levels.

This study shows that a synthetic hydrogel enables crypt formation in intestinal organoids without exogenous laminin, revealing insights into mechanical and matricellular signaling.

This study shows PTEN suppresses myofibroblast activation in valvular interstitial cells by promoting quiescence and reducing stiffness-induced activation.

The paper develops mathematical descriptors to quantify fibroblast phenotypes and validates them using drug-treated cells to predict myofibroblast activation.

The paper investigates how UTY modulates sex-specific methylation in male valvular fibroblasts in response to nanoscale extracellular matrix cues, promoting osteoblast-like cell phenotypes in aortic valve stenosis.

This study uses bottlebrush polymer hydrogels to show how strain-stiffening affects hMSC protrusion formation and mechanosensing.

This study shows that substrate stiffness anisotropy guides myotube alignment through collective cellular dynamics in C2C12 myoblasts.

The paper uses network modeling to predict gene expression and drug responses in valve myofibroblasts exposed to patient sera, linking fibrosis-related signaling to AVS severity and identifying potential therapeutic targets.