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This paper develops a Saccharomyces cerevisiae-based whole-cell biocatalyst that completely depolymerizes PET plastic using a multi-enzyme cluster, achieving 4.9 mM TPA in seven days.

This paper develops a high-density epidural stimulation paddle with integrated electronics and evaluates its long-term performance in sheep.

This study shows calcium-activated contractility is not needed for sarcomere formation but is essential for cardiomyocyte maturation and response to mechanical cues, with nanopatterns aiding maturation in non-contractile cells.

The paper develops a biomechanical model of the mouse forelimb to predict muscle activity during reaching movements, finding strong similarity between simulated and empirical muscle patterns.

This study uses CFD modeling to evaluate impeller designs for plant cell fermentation, finding that the setric impeller provides a low-shear environment with high cell-lift capabilities for Viola odorata cultures.

This study shows that Sp1 mechanotransduction enhances breast cancer cell invasion in response to combined ECM cues like stiffness, stress relaxation, and collagen density.

This paper demonstrates that engineered super-tRNAs can restore and enhance tumor suppressor protein function by overcoming nonsense mutations, leading to tumor regression in xenograft models.

This study introduces a synthetic protein, GLamouR, that binds and reports gadolinium, showing potential for bioremediation and detection of rare earth elements.

This paper introduces a new bioink called microfiber-templated porogel (FTP) bioink that enables the creation of vascularized 3D bioprinted structures with tunable porosity and in-situ endothelialization.

This study shows electrical fields direct migration of articular chondrocytes and chondrosarcoma cells in 3D collagen, with chondrosarcoma showing stronger directional response and unique protrusion behavior.

This study shows sustained delivery of multivalent influenza vaccines via polymer-nanoparticle hydrogels enhances rapid, consistent, and broad humoral immunity against homologous and heterologous strains.

This study develops a computational model to simulate retinal hemodynamics under gravitational and postural changes, showing how posture affects vessel pressures and perfusion.

This paper introduces a microfluidic platform for label-free single small extracellular vesicle counting in plasma without purification, using plasmonic nano-aperture imaging.

This paper develops a bioink for 3D bioprinting that enables in situ creation of vascularized bone tissue constructs in mouse calvarial defects.

This paper introduces VID scaffolds to enhance diffusion in neural organoids, improving their function and drug response compared to conventional organoids.

This paper describes the design and characterization of a bispecific monocyte engager targeting PSMA for prostate cancer immunotherapy, showing effective activation of monocytes and tumor cell elimination.

This paper develops a three-color single-molecule localization microscopy protocol to study chromatin structure, revealing that heterochromatin and euchromatin are not distinct territories but are spatially coupled.

This paper develops a tissue-engineered model to study how physical cues like stiffness and axonal diameter affect oligodendrocyte myelination, finding that softer substrates promote differentiation while rigid ones maintain mature states.

This study evaluates the impact of different track spike technologies on running performance in trained athletes, finding performance benefits from modern foam spikes with and without a carbon fiber plate.