Jonathan A. Kirk

The paper identifies toxic transmembrane peptides that inhibit SERCA function in DCM, offering a new mechanism for calcium mishandling in heart failure.

This paper shows that Polycystin-2 protects the heart from myocardial infarction by regulating calcium-mediated ER stress response in cardiomyocytes.

This study investigates how phosphorylation of ABLIM1's intrinsically disordered regions modulates its interaction with titin, affecting cardiac muscle contraction.

This study shows that titin cleavage in mice causes concentric cardiac remodeling, diastolic dysfunction, and fibrosis by disrupting mechanical connectivity.

This study shows calcium-activated contractility is not needed for sarcomere formation but is essential for cardiomyocyte maturation and response to mechanical cues, with nanopatterns aiding maturation in non-contractile cells.

This study identifies proteolytic degradation of atrial sarcomere proteins as a mechanism underlying contractile defects in atrial fibrillation.