Discover, rate, and discuss biology preprints.

This paper benchmarks signal peptide-mediated protein translocation in Komagataeibacter rhaeticus to enable in situ functionalization of bacterial nanocellulose during biosynthesis.

This paper evaluates a BMP-7 mRNA-lipid nanoparticle therapy for heart failure, showing improved cardiac function and reduced fibrosis in mice, along with suppression of endothelial-to-mesenchymal transition in vitro.

This paper genetically engineers K2P channels to be activated by rapamycin or its analogs, enabling chemogenetic control of cellular membrane potential.

This paper introduces nanoporous polycarbonate as a PDMS-free alternative for oxygen exchange in organ-on-a-chip systems, showing improved oxygen permeability and viability without compromising mechanical robustness.

This study develops a combinatorial chemistry approach to create biodegradable ionizable lipids for efficient mRNA delivery and gene editing in vivo.

This paper develops a machine learning framework to optimize phased-array transducers for transcranial focused ultrasound neuromodulation in mice, achieving submillimeter focal precision.

The paper engineers AAV capsids with improved muscle transduction and reduced off-target distribution in non-human primates using the REACH platform.

This paper develops a low-cost fluorogenic peptide biosensor for detecting early enamel demineralization in vitro, showing strong correlation with established QLF measurements.

This paper develops biomineralized SERS nanotags that encode biomolecular identity into machine learning-resolvable plasmonic fingerprints for diagnostic applications.

This paper develops a microneedle patch that sequentially releases three drugs to prevent vein graft restenosis after CABG, showing reduced thrombosis, intimal hyperplasia, and improved graft patency in mice.

TRACC-PHYSIO estimates physiological coupling and time delays in dynamic MRI without requiring fast acquisition, validated through simulations.

This paper develops a liquid-liquid interfacial spinning method to create cell-laden, uniaxially aligned collagen fibres with mechanical properties comparable to tendon collagen and spider silk.

The paper develops cell-permeable C16orf74 peptides that disrupt Calcineurin-NFAT interaction, inhibit T-cell activation, and show minimal cytotoxicity compared to Cyclosporine A.

This study examines the behavioral and circuit-level effects of acute and chronic gastric electrical stimulation in rodents, revealing context-dependent and temporally dynamic changes in anxiety-related behavior and neural activity.

This paper introduces 4D Oxy-wavelet MRI to non-invasively assess mitochondrial function in living brains across the lifespan, validated in mouse models and with human feasibility data.

This paper shows that mechanical stress relaxation in dendritic cells (DCs) influences their functional states, enhancing T cell priming through improved antigen presentation and migration.

The paper develops sensitive FRET biosensors to visualize CaMKII activity dynamics in living cells and demonstrates their use in cultured and primary cells, including neurons and cardiomyocytes.

This study investigates how scaffold geometry and material affect vibrational behavior under mechanical stimulation in electrospun bundles for tendon/ligament and enthesis tissue regeneration.

This study develops transgenic cassava plants using RNAi to target whitefly metabolic processes, achieving high insecticidal activity and potential for field control of whitefly populations in East Africa.

This paper calibrates penalty parameters in vascular deformation mapping using synthetic data to improve 3D aortic deformation analysis in health and disease.