Discover, rate, and discuss biology preprints.

The paper introduces a framework to analyze positional information in dynamic tissues and applies it to study cell mixing and pattern formation in developing embryos.

The paper evaluates the Turkish Light Source diffractometer for small-molecule structure determination using three rhodanine derivatives, showing reliable results with some structural challenges.

The paper investigates how two small molecule activators of PP2A, ATUX-8385 and DBK-776, affect the structural stability of the PR65 scaffold using biophysical and computational methods.

This study uses a coarse-grained model to show how spatial confinement affects DNA folding stability and conformational flexibility under varying ionic conditions.

The paper reports cryo-EM structures of the AcrAB-TolC efflux system in E. coli, revealing the role of YbjP in TolC positioning and drug transport.

This paper develops a biophysical model of human colonic motor patterns that reproduces healthy and disease states, showing how parameters affect motility.

The paper characterizes five new glycofibrils isolated from Tsinghua Lotus Pond using cryo-EM and AI, revealing structural diversity in their central protein components and glycans.

This paper uses ihMT MRI to differentiate subregions of cardiac Purkinje fibers in sheep hearts, showing higher ihMTR in free-running PF compared to insertion points and myocardium, with histology confirming collagen differences.

This study investigates how mediolateral foot placement is controlled after perturbations affecting linear or angular momentum, finding that linear momentum primarily governs foot placement.

This paper introduces a spectrolipidomic approach using deuterated cholesterol to monitor CBD-induced cholesterol changes in glial cells, revealing distinct metabolic pathways based on exposure timing.

CGAgentX develops transferable coarse-grained models using an agentic AI framework with specialized agents that autonomously optimize parameters to match experimental and simulation data.

The paper shows that growth-dependent sensory bet-hedging improves collective navigation in uncertain environments by balancing exploration and exploitation.

This study shows zebrafish epiboly is robust to mechanical perturbations, with body axis development unaffected by induced tissue flow disruptions.

The paper uses molecular dynamics simulations to study how glycosylation affects the structure, flexibility, and neurotrophin binding of p75, TrkA, and TrkB receptors.

This paper demonstrates that RGB cameras can effectively classify up to six fluorophores in SMLM with high precision, offering a cost-effective alternative to spectral imaging.

This paper shows how ionic strength affects the structural disorder and oligomerization of the Phd transcription factor, revealing its ability to function as a conformational rheostat.

This study reveals the structural mechanism of MyD88 oligomerization in innate immune signaling using cryo-EM and high-speed AFM.

The paper investigates the long-range energy transduction mechanism in Complex I using simulations and experiments, identifying key redox-triggered coupling sites.