Nieng Yan

Carbon-A annotates protein-coding genes across eukaryotic genomes using a large encoder model, achieving high accuracy and enabling the creation of a comprehensive annotation database.

The paper characterizes five new glycofibrils isolated from Tsinghua Lotus Pond using cryo-EM and AI, revealing structural diversity in their central protein components and glycans.

This study introduces Ahaha, a method for determining absolute hand of glycofibrils in cryo-EM, enabling atomic model building from natural sources.

This study uses molecular dynamics simulations to reveal the three-ion knock-on mechanism governing calcium ion permeation and valence selectivity in CaV1 channels.

This paper introduces cryoPROS, an AI method to address preferred orientation in cryo-EM, improving resolution without special experimental techniques.

The paper reports a cryo-EM structure of Chlamydomonas mastigoneme, revealing a 5',5'-phosphodiester bond stabilizing glycan folding.

The paper discovers a new glycofibril structure using CryoSeek, revealing its 8-nm diameter and unique glycan-coated tetrapeptide repeats.

The paper reports a cryo-EM structure of the HRSL domain from GCN2, revealing its role in activating the kinase and regulating the ISR pathway.

This study reports cryo-EM structures of Cav1.1 bound to DHP compounds, revealing the molecular basis for chiral specificity and drug efficacy.