Discover, rate, and discuss biology preprints.

This study quantifies Gs protein conformational transitions in response to different ligands, revealing ligand-specific dynamics that determine GPCR signaling efficacy.

This study investigates the formation of the earliest structure during protein folding on the ribosome and identifies sub-ensembles that may facilitate co-translational folding.

This study uses NMR to measure nanosecond methyl dynamics in the RNA exosome core, showing that relaxation-violated coherence transfer experiments can quantify side chain order parameters in large protein complexes.

This study compares Z22 and Z-D11 antibodies' binding to Z-NA substrates, finding they have distinct specificities and functional capabilities.

This study benchmarks metal-parameterization strategies for simulating the PAN endonuclease domain to understand resistance mutations in influenza virus.

The paper discovers that intrinsically disordered proteins form condensates with catalytic activity through sequence-dependent electrochemical microenvironments, enabling hydrolysis reactions and gene circuit activation in cells.

The paper shows that ESCRT-III-mediated membrane bending directionality arises from bilayer asymmetry rather than intrinsic ESCRT properties.

This paper introduces BNP-FRET-Bin to resolve FRET signal degeneracy and population heterogeneity by inferring state numbers and kinetics directly from FRET data, revealing new biologically relevant states.

This study investigates how anti-thrombin aptamers affect prothrombin activation by analyzing their structural interactions and binding effects.

The paper introduces a minimal model to explain how temperate phages make lysis-lysogeny decisions based on multiplicity of infection and host factors, showing how asymmetry can arise from simple coupling to host machinery.

The paper examines how small temperature variations in enzyme activation parameters affect Arrhenius/Eyring modeling, leading to apparent enthalpy-entropy compensation and misinterpretation of kinetic data.

This study develops a desolvation-aware CG model to investigate LLPS of intrinsically disordered proteins, revealing how desolvation affects phase behavior and kinetics.

The paper introduces a post-acquisition super resolution method for cryo-EM that exceeds the physical Nyquist limit by pixel doubling pre-processing, applicable to various viral and protein datasets.

This study characterizes the physical properties and conformational dynamics of Vibrio cholerae exopolysaccharides to understand their role in biofilm matrix mechanics.

This study shows that SARS-CoV-2 nucleocapsid protein interacts with viral RNA and ERGIC lipids to drive viral core assembly through lipid clustering and RNP stabilization.

This study shows that localized electric-field measurements in nanopore sensing can capture peptide charge patterns more effectively than ionic-current blockade, enabling better peptide discrimination.

This study investigates how Wnt signaling affects tissue mechanics, actin organization, and regeneration in Hydra vulgaris using pharmacological modulation.

This study characterizes MRI/CYREN's structure and function in NHEJ, showing its disordered regions bind Ku80 and multimerization enhances DNA repair efficiency.

This study uses Scanning Ion Conductance Microscopy to measure the material properties of biomolecular condensates, showing how pH and protein tags affect their stiffness over time.

Overexpressing mCherry-GST targeted to the nucleus or cytoplasm in fission yeast shifts the nuclear-to-cell volume ratio as a parameter-free colloid osmotic model predicts, retuning nucleoplasm diffusivity, condensates and heterochromatin.