Ayush Saurabh

This study reveals that Hsp104, an AAA+ ATPase, functions as a bidirectional, processive translocase by switching direction through biased stochastic conformational transitions.

This paper introduces BNP-FRET-Bin to resolve FRET signal degeneracy and population heterogeneity by inferring state numbers and kinetics directly from FRET data, revealing new biologically relevant states.

This study investigates how pore-1 loops of ATPase subunits in the 26S proteasome affect substrate degradation efficiency using biochemical and single-molecule assays with yeast proteasomes.

This paper introduces a Bayesian S-FLIM framework that learns spectra and lifetimes photon-by-photon, enabling efficient deconvolution of up to 9 fluorophore species with overlapping spectra.

The paper introduces MAESTRO, a multi-axial force application method, revealing hidden conformational dynamics in Holliday junctions under complex mechanical environments.

This paper develops a framework for simultaneous particle tracking, phase retrieval, and PSF reconstruction to improve 3D tracking of lytic granules in T cells.

This paper introduces B-SIM, an unsupervised Bayesian framework for structured illumination microscopy that improves resolution and contrast by accurately modeling noise, outperforming existing methods in both simulated and experimental data.