Discover, rate, and discuss biology preprints.

This paper introduces SweetFold, a diffusion model for predicting glycan and glycoprotein structures, showing improved performance over existing models.

This study investigates how the terminal Glc-(1-2)- in the LLO donor affects OST catalytic efficiency through molecular dynamics simulations of yeast OST with and without this motif.

This study investigates mechanosensory responses in tintinnid ciliates, revealing a novel form of cilia-associated habituation to mechanical stimuli.

This study uses ultrafast X-ray scattering to observe retinal cis-trans isomerization in rhodopsin, revealing how cofactor dynamics drive activation without crystal lattice constraints.

The paper shows weak magnetic fields affect Xenopus laevis tadpole pigmentation in a light- and eye-dependent manner consistent with the radical pair mechanism.

This study uses molecular dynamics simulations to investigate whether parallel Holliday junctions exist in solution, finding they are thermodynamically metastable but rarely observed.

The paper investigates how transcription and loop extrusion create spatial confinements that regulate genomic encounters in the immunoglobulin heavy chain locus.

This study investigates how gain-of-function variants in the Kv7.2 channel's activation gate stabilize a partially open conformation, enabling K+ permeation and linking it to neurodevelopmental disorders.

This study develops a multiscale cytoskeletal network model to simulate shear rheological properties and their evolutionary mechanisms, revealing how chemo-mechanical coupling and actin filament dynamics influence cellular mechanical responses.

This paper develops a model linking accumulated neurotoxicity from amyloid beta oligomers to biological age, showing that increasing half-lives of Aβ monomers and oligomers accelerates aging.

Quinoa provides efficient and robust CTF estimation for cryoET tilt series, improving automated structural analysis of cells and tissues.

The paper investigates how bacteria control flagellar number through assembly-coupled feedback, showing robustness arises from a balance between intrinsic fluctuations and regulator variability.

The paper shows that the disordered C-terminal segment of Skp1, H8, nucleates helices but limits their propagation through a charge-sensitive rheostat, maintaining conformational flexibility.

The paper introduces CGUI-CLD, a web-based platform for covalent ligand docking that automates ligand preparation and simulation using AutoDock4.

The paper introduces OASSIS, an open-format digital bioassay platform that enables sensitive, low-complexity RNA detection for point-of-care testing.

This study maps the mutational landscape of SOD1 by analyzing monomer folding and dimerization, identifying protein destabilization as a key driver of ALS and uncovering potential therapeutic targets.

This study models soil organic carbon in the Andes using machine learning with crop rotation data, finding that fallow frequency is a key predictor of SOC when soil data are excluded.

FENNEC classifies bursts in diffusion-based smFRET data into conformational dynamics and photophysical artefacts using simulated data, without requiring labeled experimental data.

This paper introduces GZL626, a novel AR degrader that targets the N-terminal domain and RNF213-UBE2J2 complex, effectively degrading AR and AR-V7 and showing antitumor and antiviral activity.

This paper develops a new methodology to model phosphoinositide signaling dynamics, showing that basal PI(4)P levels determine cell-specific responses to genetic perturbations.