Peijun Zhang

The paper determines the structure of HIV-1 capsid lattice bound to MxB N-terminal fragment, revealing an alpha-helix stabilizes binding at the trimer interface.

The paper determines the structure of native chloroplast ribosomes in Chlamydomonas reinhardtii and identifies lineage-specific extensions linked to ribosome dynamics and evolution.

Quinoa provides efficient and robust CTF estimation for cryoET tilt series, improving automated structural analysis of cells and tissues.

The paper maps thylakoid membrane biogenesis in Chlamydomonas reinhardtii using integrated imaging and proteomics, revealing decentralized synthesis and hierarchical assembly of photosynthetic complexes.

This study presents 43 cryo-EM structures of RNAPII elongation complex during the nucleotide addition cycle, revealing structural dynamics and transition intermediates.

This study visualizes chromatin structure and HIV-1 nuclear trafficking in situ, showing HIV-1 cores preferentially associate with open chromatin and are excluded from compact regions.

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.

This study uses cryo-ET to reveal the structure and dynamics of native pyrenoid Rubisco in Chlamydomonas reinhardtii, showing variations in active site and dimer interface and associations with binding proteins.

The paper introduces Di-Gluebodies, covalently-dimerized nanobodies, to improve cryo-EM structure determination of small proteins by providing rigidity and modularity.

The paper identifies two synthetic peptides that potently and selectively modulate ASIC3 activity, showing similar effects but differing in washout kinetics.

This study uses cryo-correlative techniques to analyze HIV-1 nuclear import, revealing dependencies on capsid elasticity, nuclear pore adaptability, and CPSF6 binding.

This study uses cryo-ET to capture complete SARS-CoV-2 fusion intermediates, revealing structural changes and the inhibitory effect of the WS6 S2 antibody.

This study shows that an ordered mature MA lattice is not required for HIV-1 infectivity, as a triple mutant lacking this structure remains infectious.

This study identifies galactosyrin, an iminosugar produced by Pseudomonas syringae, which inhibits plant β-galactosidase and alters host glycobiology to aid infection.

This paper identifies a mutation, G225R, that restores capsid formation and infectivity to HIV-1 mutants deficient in IP6 packaging by stabilizing the capsid structure in low-IP6 conditions.

Cryo-ET of 169 nm β-carboxysomes from low-light Synechococcus elongatus reveals ~639 Rubiscos in concentric layers with CcmM bound at RbcL grooves; QconCAT proteomics yields the complete absolute protein stoichiometry.

This study reveals the 3D structure of native chromatin fibres in human T-lymphoblasts using cryo-ET, showing a relaxed, variable zigzag organization of nucleosomes.

This study determines the native structure of ChAdOx1-vectored SARS-CoV-2 vaccines on cell surfaces, showing prefusion spikes in one-RBD-up conformation and improved RBD exposure in HexaPro-stabilized variants.

The paper investigates the role of intrinsically disordered CsoS2 in α-carboxysome shell assembly using synthetic engineering and cryoEM structures, revealing its function as a molecular thread and identifying a conserved interaction motif.

The paper determines the structure of immature HERV-K VLPs using cryoET STA, revealing conserved assembly mechanisms across retroviruses.