Discover, rate, and discuss biology preprints.

This paper benchmarks AI structure predictors on fuzzy protein complexes, finding they consistently violate 30% of NOE restraints and show poor helicity correlation with thermodynamic expectations.

This study shows that geometric confinement affects ERK signaling and collective migration in epithelial tissues by altering mechanical states through actomyosin contractility.

This study identifies small molecule inhibitors of the NaCT transporter by targeting an allosteric site, revealing a chemically distinct series with improved potency.

The paper uses simulations to study how Mg2+ ions influence the folding and stabilization of the GAAA tetraloop-receptor interaction in a group I intron.

The paper infers enhancer-specific transcription factor interactions from gene expression data using a biophysical model and validates it with simulated and experimental data.

The paper studies how sperm navigate near walls in flowing fluids, identifying a new oscillation state and a hydrodynamic buffer zone that stabilizes surface navigation.

The paper shows that chaperonin GroEL/S promotes drug resistance by recognizing protein dynamics, displacing inhibitors and restoring active enzyme function.

The paper investigates how fusion peptides from enveloped viruses mediate membrane fusion in model cell membranes using microfluidic devices and fluorescence microscopy.

The paper uses molecular dynamics simulations to show how Aspein, an acidic protein from pearl oysters, controls calcium carbonate polymorphism by sequestering Ca2+ and stabilizing calcite over aragonite.

This study evaluates the impact of tension-compression switches in the GOH model on brain anisotropic modeling, showing that switching parameters and fiber treatment affect WM deformation.

The paper identifies macrocyclic peptides that disrupt the CHD4-GATAD2A interaction in NuRD, revealing CHD4's role as an interaction hub and suggesting a therapeutic strategy for beta-hemoglobinopathies.

This study investigates how recipient cell identity influences intracellular transport and membrane interactions of extracellular vesicles across species, finding that recipient-cell environment has a greater impact than EV origin.

This study shows ANKLE1 is a tension-stimulated endonuclease that cleaves DNA branchpoints under high tension, aiding in resolving interchromosomal bridges during mitosis.

This paper introduces a workflow combining SHG and AFM for label-free collagen analysis in tissue sections, improving specificity and throughput.

This study examines the nonlinear rheology of laminin-111-modified hyaluronan hydrogels, finding that laminin concentration affects their mechanical behavior and strain response.

This paper studies the G768R mutation in cardiac myosin, showing it increases the duty ratio to >60%, leading to hypercontractility and impaired relaxation.

The paper develops a computational model to show that molecular diffusion and binding kinetics can explain nuclear protein clustering without requiring phase separation or protein-protein interactions.

This study identifies a dual-targeting strategy for bacterial adaptive evolution by inhibiting two metabolic enzymes in the folate pathway, demonstrating constrained evolutionary trajectories with Arbutin.

This paper designs a DNA-based nanoscale Jitterbug transformer that reconfigures its structure in response to chemical and optical signals, maintaining a Poissons ratio of -1.

This study introduces ExVivo PhaseScan to generate high-resolution phase diagrams of physiological protein condensates and reveals how FUS mutations cause liquid-to-solid transitions in stress granules and nucleoli.