Tomas Šneideris

This study uses acoustic trapping to measure the mechanical properties of single biopolymer condensates, showing it can detect changes in bulk modulus under different environmental conditions.

This study introduces ExVivo PhaseScan to generate high-resolution phase diagrams of physiological protein condensates and reveals how FUS mutations cause liquid-to-solid transitions in stress granules and nucleoli.

This study characterizes liquid-liquid phase separation driven by RSV proteins and RNA, identifying key interactions and stoichiometric requirements for condensate formation.

This study shows that biomolecular condensates can sustain pH gradients without energy input by neutralizing charges, revealing their role in creating pH microenvironments.

This paper introduces a dominance analysis framework to determine the molecular mechanism of condensate modulation, demonstrating its application to G3BP1/RNA condensates disrupted by suramin.

The paper investigates anisotropies in RNA-based biomolecular condensate interfaces, finding that purine-rich RNAs drive phase separation while pyrimidine-rich RNAs accumulate at interfaces, with distinct motion patterns observed using single-molecule imaging.

The paper investigates thyroglobulin phase separation in thyroid follicles, showing it forms storage depots and reveals a mechanism for hormone homeostasis.

This paper shows that Alzheimer's amyloid-beta peptide forms biomolecular condensates on lipid bilayers, accelerating amyloid aggregation and revealing a new early step in the disease mechanism.

This study designs a synthetic biomolecular condensate platform using CTPR proteins and intrinsically-disordered domains to tune condensate properties and recruit target proteins.

This study investigates how the fusion of biomolecular condensates, influenced by ageing and mixing rates, leads to the formation of multiphase structures with distinct material properties.

The paper investigates how temperature affects G3BP1-RNA phase separation, revealing that while the phase boundary remains stable, stoichiometry and energetics shift, driven by entropic processes.