Discover, rate, and discuss biology preprints.

The paper develops statistical methods to estimate variance and covariance of R2 values for polygenic scores, enabling significance testing of predictive ability differences across samples and SNP types.

The paper shows that the attP40 transgenic landing site in Drosophila disrupts Or47b olfactory receptor neuron glomerular organization, suggesting potential genetic interactions or background effects.

The paper estimates transcription fidelity in human cells, identifies factors controlling its accuracy, and links transcription errors to Alzheimer's disease progression.

This study identifies Adr1 as a transcription factor regulating ergosterol pathway and azole resistance in C. albicans, with functional interactions with Upc2.

This paper compares traditional and chatbot-based consent processes for genomics research, finding shorter consent times and positive participant feedback with the chatbot.

This study models toxin-antidote gene drives using Wolbachia's CifA and CifB genes, finding they can create confined drives with varying introduction thresholds and persistence depending on ecological factors.

This paper shows that f-statistics can be biased when using non-outgroup SNP ascertainment schemes and proposes a pan-African ascertainment approach to reduce bias in population history inference.

This study identifies and functionally characterizes IsAQP1, an aquaporin in Ixodes scapularis, showing it is a water channel with low glycerol permeability and salivary gland-specific expression.

This paper introduces a Bayesian framework to infer temporally variable selection from ancient DNA data by modeling genotype likelihoods and sample uncertainties, demonstrating improved selection inference using ancient horse coat color loci.

This paper describes the optimization of base editing to correct the SMN2 exon 7 mutation in SMA, achieving high editing efficiency and increased SMN protein levels in vitro and in vivo.

The paper identifies a FOXP4-driven transcriptional network in human neutrophils responding to inflammatory stimuli, including LPS, and shows its regulation of proinflammatory genes.

The paper develops a system for rapid, site-specific integration of multiple DNA constructs into the E. coli chromosome using recombinases, demonstrating its utility by inserting DNA methyltransferases to enable transformation of Clostridium clariflavum.

The paper introduces a fast algorithm for jointly inferring FST parameters and genetic structure trees from allele count data, applied to human populations and individuals.

The paper develops Paraphase, a method using long-read sequencing to accurately determine SMN1 and SMN2 haplotypes and copy numbers, improving silent carrier detection in spinal muscular atrophy.

This paper introduces a method to induce targeted recombination in C. elegans using Cas9, enabling high-resolution genetic mapping in species with low natural recombination rates.

The paper develops a multi-omics Mendelian randomization framework to identify transcript-metabolite-trait causal triplets and shows it outperforms classical transcriptome-wide MR by integrating multiple omics layers.

The paper identifies parent-of-origin effects on the methylome linked to aging rates by analyzing CpG methylation in a large family cohort.

The paper integrates top-down and bottom-up approaches to study speciation in a monkeyflower hybrid zone, finding that reproductive isolation involves widespread genomic barriers and polygenic traits.

The paper identifies SNVs in coral sperm and somatic tissue, suggesting lifelong stem cell renewal and lineage selection in corals.

The paper shows that missense mutations in kinetochore proteins reduce chromosome instability in histone-humanized yeast by weakening microtubule attachments, promoting euploidy.