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The paper reviews current methods for Mendelian randomization and proposes a regression calibration approach to correct for bias in causal effect estimates using GWAS summary data.

The paper identifies miRNA-eQTLs in human neocortical tissue, linking miR-4707-3p expression to brain size and educational attainment through colocalization with GWAS data.

The paper identifies CoRSIVs with strong genetic control of methylation and links them to transposable elements and disease.

This study analyzes genetic variation in the Catalan Pyrenees, finding micro-population substructure influenced by historical bishoprics rather than geographic barriers.

This study investigates how one-carbon metabolic enzymes regulate cell cycle progression and metabolome in Saccharomyces cerevisiae, showing distinct effects of enzyme loss on cell size, growth, and metabolic profiles.

This study identifies genetic loci associated with exploratory locomotion and anxiety-like traits in a selectively bred rat model using a genome-wide association approach.

This study identifies host gene expression patterns associated with HIV reservoir size in treated individuals, linking inflammation, innate immunity, and potassium/gap junction channels to viral persistence.

This study shows that reducing PKD2 activity in mice prevents bleomycin-induced dermal fibrosis by decreasing collagen and inflammatory markers.

This study characterizes multidrug-resistant ESBL-producing K. pneumoniae isolates from a DRC hospital, identifying genetic diversity and resistance patterns.

This study uses mitochondrial DNA analysis to investigate the genetic diversity and evolutionary origins of Philippine native pigs, revealing their ancestry from three Sus scrofa lineages and no domestication from endemic wild pigs.

This study shows that piRNA pathway downregulation in the germline during mating releases Hedgehog signaling, leading to somatic aging and reduced lifespan.

The paper shows that yeast cells with elevated chromosome numbers are dependent on Mps1 for proper chromosome orientation during mitosis, revealing a mechanism for Mps1 addiction in aneuploid cells.

This paper introduces a method to detect rare DNA methylation outliers in schizophrenia and finds an increased burden of these outliers in cases compared to controls.

The paper investigates the functional interdependence of sister replisomes in E. coli, showing that their physical association in a factory configuration enhances replication efficiency and reduces fork stalling.

The paper identifies new alleles in eIF4E and eIFiso4E genes from Prunus species that are linked to resistance against Plum Pox Virus (PPV).

The GLAD Project compiles genome-wide data from 54,077 Latin Americans and develops tools for ancestry matching and statistical software evaluation in admixed populations.

The paper profiles H3K27ac in brain cell types from AD patients and finds acetylation differences in oligodendrocytes linked to AD risk genes and pathways.

FLARE infers local ancestry with high accuracy and efficiency, scaling to large datasets using advanced computational techniques.

This study investigates the role of BCL2L13 and autophagy in mtDNA purifying selection by analyzing knockout models in mice.

The paper identifies DNA methylation signatures associated with NSD2 loss-of-function variants and shows their similarity to those in Wolf-Hirschhorn syndrome.