B. Guo

Benchmarking and Optimization of Methods for the Detection of Identity-By-Descent in High-Recombining Plasmodium falciparum

This study benchmarks IBD detection tools for Plasmodium falciparum, showing that optimized parameters improve accuracy, especially for Ne estimation, and recommends hmmIBD for quality-sensitive analyses.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

Strong Positive Selection Biases Identity-By-Descent-Based Inferences of Recent Demography and Population Structure in Plasmodium falciparum

This study shows that positive selection biases IBD-based demographic and population structure inferences in Plasmodium falciparum and suggests removing IBD peak regions to correct these biases.

Multiplexed Amplicon Sequencing Reveals High Sequence Diversity of Antibiotic Resistance Genes in Quebec Sewers

This study uses multiplexed amplicon sequencing to detect sequence variants of antibiotic resistance genes in Quebec sewers, revealing high diversity and varying public health risks.

Antibiotic Resistance Gene Variant Sequencing is Necessary to Reveal the Complex Dynamics of Immigration from Sewers to Activated Sludge

This study investigates ARG immigration dynamics between sewers and activated sludge using sequencing and PCR to show that over 70% of ARGs increase in abundance due to immigration.

Activated Sludge Microbial Community Assembly: The Role of Influent Microbial Community Immigration

This study investigates how influent microbial immigration affects activated sludge communities in wastewater treatment plants, finding that immigrants contribute up to 25% of sequencing reads.

Genetics of Latin American Diversity (GLAD) Project: insights into population genetics and association studies in recently admixed groups in the Americas

The GLAD Project compiles genome-wide data from 54,077 Latin Americans and develops tools for ancestry matching and statistical software evaluation in admixed populations.

Cell type-specific attenuation of brassinosteroid signalling drives stomatal asymmetric cell division

The paper shows that BR signaling is attenuated in stomatal precursor cells but remains active in differentiating epidermal cells, mediated by scaffold proteins.

Wastewater Influent Microbial Immigration and Contribution to Resource Consumption in Activated Sludge Using Taxon-Specific Mass-Flow Immigration Model

The paper develops a mass-flow immigration model to quantify influent microorganism immigration efficiency and their contribution to organic substrate consumption in activated sludge.

Porous microneedle patch with sustained exosome delivery repairs severe spinal cord injury

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

Impact of pH and removed filtrate on E. coli regrowth and microbial community during storage of electro-dewatered biosolids

This study examines how pH and filtrate removal affect E. coli regrowth and microbial communities in electro-dewatered biosolids, finding pH as the main inhibitor of bacterial regrowth.

Withaferin A promotes white adipose browning and prevents obesity through sympathetic nerve-activated Prdm16-FATP1 axis

This study shows that Withaferin A promotes white adipose browning and prevents obesity by activating the Prdm16-FATP1 pathway via the sympathetic nervous system.

Local brassinosteroid biosynthesis enables optimal root growth

This study shows that local brassinosteroid biosynthesis in the root elongation zone supports optimal root growth by creating a hormone concentration gradient that aligns with signaling maxima.

Phytophthora sojae effector Avr1d functions as E2 competitor and inhibits ubiquitination activity of GmPUB13 to facilitate infection

This study identifies Avr1d as a Phytophthora sojae effector that inhibits GmPUB13 E3 ligase activity by competing with E2 ubiquitin conjugating enzymes, stabilizing the susceptibility factor and facilitating infection.

Precise exogenous insertion and sequence replacements in poplar by simultaneous HDR overexpression and NHEJ suppression using CRISPR-Cas9

This paper improves HDR efficiency for gene knock-in in poplar by combining XRCC4 silencing with CtIP and MRE11 overexpression, achieving higher knock-in rates and fewer InDels.

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

Genetic population structure constrains local adaptation in sticklebacks

The paper identifies genetic factors underlying pelvic reduction in sticklebacks and shows how population structure limits local adaptation.

Native protein delivery into rice callus using ionic complexes of protein and cell-penetrating peptides

This study delivers a fluorescent protein into rice callus using ionic complexes of cell-penetrating peptides and shows varying efficiency across callus growth stages.

Carbohydrate, glutathione, and polyamine metabolism are central to Aspergillus flavus oxidative stress responses over time

This paper identifies metabolite pathways involved in oxidative stress responses of Aspergillus flavus over time, linking them to aflatoxin production and stress tolerance.

Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis

This study shows that PLEKHO1 in osteoblasts worsens joint inflammation in RA and promotes bone formation, suggesting it as a therapeutic target.

A negative feedback mechanism in the insulin-regulated glucose homeostasis in Japanese flounder Paralichthys olivaceus by two ways of glucose administration

This study compares glucose administration methods in Japanese flounder, showing different insulin and brain-gut peptide responses, and suggests a negative feedback mechanism in glucose homeostasis.