Nils‐Göran Larsson

This study shows that respirasomes are not essential for maintaining respiratory-chain complexes after their assembly, even under mitochondrial stress or impaired OXPHOS biogenesis.

This study identifies a novel link between ATP synthase and the TCA cycle using crosslinking mass spectrometry, showing how ATP synthase interacts with TCA cycle enzymes and adapts under mitochondrial dysfunction.

This study investigates tissue-specific effects of TFAM and mtDNA copy number manipulation in mtDNA mutator mice, revealing both beneficial and detrimental outcomes depending on the tissue.

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

This study shows that PARKIN is not required for OXPHOS function in adult mammalian tissues, using mouse models and a patient with PARKIN deficiency.

This study shows that increased POLRMT levels enhance mitochondrial transcription initiation but do not increase OXPHOS biogenesis due to downstream regulatory limitations.

This study shows that mice with reduced respirasomes maintain normal bioenergetics and physiology, suggesting respirasomes are not essential for basic function but may have other roles.

This study investigates the role of BCL2L13 and autophagy in mtDNA purifying selection by analyzing knockout models in mice.