Discover, rate, and discuss biology preprints.

This study shows that NLRP6 inflammasome activation by polymicrobial interactions drives IL-1β production and alveolar bone loss in a mouse model of periodontitis.

This study shows that repeated shrimp allergen exposure leads to 5-lipoxygenase-dependent avoidance and specific gut-brain activation in mice.

This study shows that neutrophil phagocytic activity in S. aureus infection is driven by prior pathogen encounters rather than tissue dwell time.

SemVac uses LLMs to predict vaccine antigens by analyzing literature-derived protein descriptions, outperforming existing methods and identifying new candidates with experimental validation.

This study shows melanoma suppresses galectin-9 on dendritic cells, and restoring it limits T regulatory cell expansion, suggesting a new therapeutic target.

This paper develops a third-generation IL-2 therapeutic that targets inflamed tissues via oxidation-specific epitopes, showing improved therapeutic benefit in multiple inflammation models.

PAIR-Scan identifies potent TCR-neoantigen pairs from tumor samples through library-on-library screening, enabling efficient analysis of T cell reactivity.

This study shows that F. tularensis modulates the macrophage redox environment to suppress Aim2 inflammasome activation, revealing a mechanism by which it evades host immune responses.

This study shows that the ENPP1 K173Q variant reduces cGAMP hydrolysis, leading to increased extracellular cGAMP and insulin resistance in brown adipose tissue.

The paper establishes a CRISPR/Cas9 screening platform in hiPSC-derived macrophages to identify genetic targets influencing inflammatory responses and functional phenotypes.

This study shows that γδCAR T-cells outperform conventional CAR T-cells in an ovarian cancer-like tumor microenvironment despite lower viability.

This study shows that albumin-fused IL-10 reduces experimental autoimmune encephalomyelitis by enhancing immunoregulation in secondary lymphoid organs.

This study compares spatial immune architectures in tumor and tumor-adjacent tissues of early-stage NSCLC, finding distinct immune cell densities, spatial patterns, and associations with genomic features and patient outcomes.

This study establishes a mouse model to investigate adaptive immunity to oral Shigella infection and identifies CD4+ T cells as critical for cross-serotype protection through IFN-gamma and IgA production.

This study characterizes immunoglobulin loci in two orangutan species using genomic analysis and IMGT-based curation, revealing haplotype-specific variation and conserved regulatory motifs.

The paper identifies MHC-II epitopes in C. neoformans chitin deacetylases that stimulate CD4+ T cells and demonstrates their protective role in a hybrid protein vaccine.

The paper identifies eicosanoid-enriched follicular microenvironments in HIV-infected individuals on antiretroviral therapy that may influence antibody responses and viral reservoir persistence.

This study identifies IL-27 as an inducer of a distinct CD4+ cytotoxic T cell program that differs from Th1 lineage.

The paper shows mitochondrial state influences protein-level immune responses, with OXPHOS supporting early immune proteins and mitochondrial perturbation favoring inflammatory mediators in mice.

This study shows that intact extracellular vesicles from infected cells are necessary for durable memory T cell immunity and Th1 responses after mucosal immunization, while total antibody induction remains unaffected by vesicle disruption.