Discover, rate, and discuss biology preprints.

The paper uses acoustic microscopy to monitor tissue degradation by enzymes, showing how specific components are removed or preserved through AOS imaging.

This study identifies suppressive myeloid cell populations in human TB granulomas using spatial transcriptomics and single-cell immunophenotyping, revealing IDO1+ dendritic cells as key regulators of immune suppression.

This paper identifies SUGR1 as a master regulator in nematodes that orchestrates effector production, essential for host entry and parasitism, and shows blocking SUGR1 prevents parasitism.

This paper introduces BEPH, a lightweight foundation model for cancer diagnosis and survival prediction from histopathological images, showing improved performance over existing models with limited data.

This study integrates single-cell and spatial transcriptomics with histopathology to identify cellular and molecular changes in lung alveolar damage during COVID-19 progression.

AGP-Net predicts spatial gene expression from histopathology images by leveraging textual gene descriptions to generalize across unseen genes and datasets.

The paper identifies a new Lolavirus species, PaLV, infecting seashore paspalum, characterizes its genome, and develops a detection method.

This study shows that grapevine vigour is positively correlated with EBDA incidence, but high vigour can also correlate with variable symptom expression, suggesting additional factors are involved.

This study characterizes RPE structure and lipid changes in a ZSD mouse model, identifying lipid alterations that precede and accompany retinal degeneration.

The paper identifies Aqp1 as critical for lacteal maintenance and inflammatory lymphatic remodelling through single-cell RNA-sequencing and genetic studies in mice.

This paper introduces Adaptive Example Selection (AES), an XAI framework for mitosis detection that enhances model interpretability by comparing test cases with annotated prototypes.

This study shows LRP2 levels are reduced in non-syndromic high myopia and posterior staphyloma, and its expression is modulated by light and cortisol.

This study predicts West Nile Virus risk across Europe using species distribution modeling, showing increased risk in some areas and decreased risk in others under future climate scenarios.

The study evaluates host plants preferred by Asian citrus psyllid, finding curry leaf plant most effective for attracting the pest, with lower nymphal mortality compared to other hosts.

This study shows that REEP6 deficiency causes retinal degeneration by reducing phototransduction proteins due to ER and Golgi dysfunction and inflammation.

This paper develops a multimodal transformer model using H&E images and text reports to predict recurrence scores in hormone receptor-positive breast cancer, achieving high accuracy and generalizability.

In 415 European and Mediterranean wheat powdery mildew genomes, fungicide-resistance mutations rose over time with regional patterns; demethylation-inhibitor resistance at cyp51 emerged at least twice independently and spread.

This study shows that TCV's coat protein suppresses RNA decay by degrading AtDcp1 via ubiquitination and autophagy, enhancing viral infection.

This study tracks cardiac changes in DE50-MD dogs with DMD, showing worsening fibrosis and function decline over time, validated by CMR and histopathology.

This study identifies metabolic impairments and oxidative stress in Prpf31 mutant mouse RPE cells as key factors in retinitis pigmentosa pathogenesis.