Neharika Jain

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

This study identifies Mtb genes essential for survival in vaccinated and previously infected hosts using TnSeq, revealing differences in genetic requirements across immunization strategies.

This study identifies suppressive myeloid cell populations in human TB granulomas using spatial transcriptomics and single-cell immunophenotyping, revealing IDO1+ dendritic cells as key regulators of immune suppression.