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This study examines how endurance exercise affects liver metabolism in male and female rats over time, revealing sex-specific molecular changes and protective effects.

The paper shows dietary lipid is deposited in skin, altering its thermal properties and energy regulation within days.

The paper evaluates the postural stimulation test (PST) to differentiate primary aldosteronism from low-renin hypertension using multivariate analysis of clinical and endocrine data.

This study shows that LPS differentially affects phagocytosis in M1- and M2-like macrophages via PGE2 and EP4 signaling, with NSAID inhibition increasing phagocytosis in M1-like macrophages.

This study shows Lactobacillus modulates the gut microbiome to reduce inflammation and improve RV function in PAH by counteracting GP130-mediated microtubule remodeling.

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.

This study identifies TRPV4-expressing macrophages as regulators of lymphatic vessel function through TXA2 receptors, suggesting therapeutic targets for lymphedema.

This study identifies the C-terminal domain as the temperature sensor in TREK channels and shows that microtubule interaction and PKA phosphorylation regulate their thermosensitivity.

This study investigates the proteomic changes in human skeletal muscle during energy deficit combined with aerobic exercise, revealing shifts toward an oxidative phenotype and metabolic adaptations.

This study shows that desmoplakin loss causes PKC-dependent sarcomere shortening and contractile dysfunction in cardiomyocytes, leading to heart failure.

The paper examines how nonphotochemical quenching (NPQ) varies with abiotic stressors and developmental stages across plant species, revealing species- and genotype-specific responses.

This study shows that de novo ceramide synthesis in beta-cells is essential for normal insulin production and glucose tolerance, as its inhibition leads to reduced beta-cell mass and impaired glucose regulation.

This study constructs dose-response curves for lower body negative pressure (LBNP) to quantify cardiovascular effects across different postures and identifies its potential to reduce jugular venous flow stagnation during spaceflight.

This study examines how apocarotenoids like ionones and abscisic acid affect growth, sporulation, toxin production, and gene activity in two Fusarium oxysporum strains, revealing strain-specific responses.

This paper develops a deep learning-based method to isolate and classify Purkinje fiber cells from adult sheep hearts using imaging data and validation techniques.

This study uses speckle tracking echocardiography to compare contractile reserve in old and obese mice, finding distinct functional phenotypes in their cardiac responses to preload and sympathetic stimulation.

The paper uses single-cell RNA sequencing to show exercise increases Zbtb16 expression and suppresses oxidative stress and metabolism in murine skin vascular endothelial cells.

This study shows metformin protects the heart from chronic intermittent hypoxia by activating AMPK2, which phosphorylates and inhibits HIF-1α, reducing mitochondrial damage.

This study compares phosphorus bioaccessibility of processed soy and pulse protein products with animal protein products using in vitro digestion, finding some plant-based alternatives have lower bioaccessible phosphorus.

This study shows that Tldc2 knockout in B-type kidney intercalated cells impairs urine alkalinization and bicarbonate secretion, suggesting Tldc2's role in renal acid-base regulation.