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Shiou Ping Chen

Centre National de la Recherche Scientifique

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Physiology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1

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Céline Cruciani‐GuglielmacciiD· 1 shared Chloé AmouyaliD· 1 shared Chr̀istophe MagnaniD· 1 shared Eleni GeorgiadouiD· 1 shared F. MifsudiD· 1 shared Guy A. RutteriD· 1 shared Hervé Le StunffiD· 1 shared Ilyès RahoiD· 1 shared

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Céline Cruciani‐GuglielmacciORCID

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1 paper

Recent·Most cited

PhysiologybioRxivPreprintMay 14, 2025

Serine palmitoyltransferase-mediated de novo sphingolipid biosynthesis is required for normal insulin production and glucose tolerance

Chloé Amouyal, Shiou Ping Chen, Jessica Denom…·Chr̀istophe Magnan

This study shows that de novo ceramide synthesis in beta-cells is essential for normal insulin production and glucose tolerance, as its inhibition leads to reduced beta-cell mass and impaired glucose regulation.

DOI 10.1101/2025.05.14.653935

mousebulk RNA-seq

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