Author

Sébastien Chaigne

Electrophysiology and Heart Modeling InstituteORCID 0000-0002-7141-8469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Fabien BretteiD· 2 shared Michel Haı̈ssaguerreiD· 2 shared Olivier BernusiD· 2 shared Akinola Alafiatayo· 1 shared Ayoub El Ghebouli· 1 shared Bruno D. M. Y. StuyversiD· 1 shared Bruno QuessoniD· 1 shared Catherine Rücker‐MartiniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPhysiology

Fabien BretteORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintMay 13, 2025

AI-based identification of cardiac Purkinje fiber cells isolated from whole adult sheep hearts

Sébastien Chaigne, Thomas Hof, Kristell Mimoun…·Olivier Bernus

This paper develops a deep learning-based method to isolate and classify Purkinje fiber cells from adult sheep hearts using imaging data and validation techniques.

1 citation

imagingdeep learning

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Cell BiologybioRxivPreprintOct 23, 2023

Increased spontaneous Ca2+ activity in Cardiac Purkinje cells after myocardial infarction; A consequence of a dramatic shift of SERCA isoforms as potential adaptation to acute ischemia?

Bruno D. M. Y. Stuyvers, Penelope A. Boyden, Ruhul Amin…·Touati Benoukraf

This study shows that increased spontaneous Ca2+ activity in cardiac Purkinje cells after myocardial infarction is due to a shift in SERCA2 isoforms, specifically increased SERCA2b and reduced SERCA2a.

DOI 10.1101/2023.10.23.563678

humanmouse

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