Discover, rate, and discuss biology papers.

This study evaluates EQ12, a quaternary ammonium compound, showing broad antimicrobial activity against SSTI pathogens with good biofilm inhibition and resistance prevention.

The paper examines how odorant representations in the olfactory bulb are structured by concentration-dependent tuning of functionally distinct OSN subpopulations across different concentration regimes.

This paper evaluates six PMSG ELISA kits, finding inconsistent quantitative results due to calibration-material differences and assay variability.

The paper constructs state-level regulatory networks in mouse liver hepatocytes, revealing an invariant sub-network of broadly expressed TFs that defines cell-type identity, distinct from state-specific variations.

The paper shows that hippocampal place cells maintain spatial information through intrinsic persistent firing via TRPC4 channels during working memory tasks in mice.

This study shows that temporal changes in the phyllosphere microbiome have a greater impact on antibiotic resistance gene abundance than fungicide treatment.

This study thermo-adapts an IHNV virus to 25°C and shows it remains virulent in zebrafish at 20°C and 25°C, with altered immune response and transmission routes.

FASN-driven lipogenesis sustains EGFR palmitoylation and PI3K-AKT-mTOR signaling, suppressing tumor MHC-I antigen presentation; blocking it curbs TNBC metastasis in mice via CD8 T cell recognition.

The paper evaluates methodological choices for analysing circadian activity data and identifies optimal approaches for different scenarios.

This study quantifies mechanical differences in human macrophages based on polarization state using atomic force microscopy.

The paper compares mammalian and C. elegans orthologs of Synaptotagmin-1 and Complexin in a single-vesicle assay to understand their roles in synaptic vesicle clamping and neurotransmitter release.

The paper uses charge detection mass spectrometry to detect protein nanoclusters, revealing their mass dispersion and polydispersity as intermediates in phase separation.

The paper develops a workflow to reduce and repair dynamic metabolic models of CHO cells using identifiability analysis and metabolic flux analysis, improving prediction accuracy for specific growth rate and productivity.

This study identifies TMEM106B as an alternative receptor for SARS-CoV-2 S-E484D variant entry, independent of ACE2, in airway-derived cell models.

The paper analyzes 3D trajectories of chromosomes and spindle poles to reconstruct spindle forces in prometaphase, finding that pole-pole segregation is robust and primarily driven by interpolar forces.

The paper shows CDC25B promotes spinal cord neurogenesis by coordinating cell cycle progression with ribosome biogenesis, leading to increased translation in differentiating neurons.

Zebrafish larva infection experiments plus pharmacokinetic-pharmacodynamic (PKPD) modelling gave bedaquiline's in vivo Emax and EC50 against M. marinum in about 2 months; waterborne clarithromycin barely entered larvae.

This study investigates how empathy influences social conformity through physiological arousal, visual attention, and socio-emotional traits using a combination of behavioral and physiological measures.

This study develops a model linking nuclear hydration to chromatin phase organization and mechanics, showing how osmotic and mechanical cues influence chromatin structure through water content and histone dynamics.

This study uses a nematic framework to show that endothelial cell orientation gradients drive angiogenic sprouting, with implications for therapeutic strategies.